Senior Scientist - Bioanalytical & Biomarker Technologies

About the role

A highly motivated bioanalytical scientist will contribute to the development and implementation of state-of-the-art quantitative and qualitative analytical and bioanalytical methods to support biopharmaceuticals in Regeneron’s discovery and preclinical development pipeline. The role requires functioning well in a collaborative, fast-paced, multidisciplinary team environment.

Responsibilities

• Develop LC-MS–based bioanalytical methods in various biological matrices.
• Apply these methods to quantify biotherapeutic levels, assess in vitro stability, evaluate in vivo biotransformation, and measure biomarkers (small molecules, peptides, and proteins).
• Support characterization of drug candidates and critical reagents within the discovery pipeline.
• Collaborate closely with chemistry, conjugation, biology, PK, and TK teams to ensure strong experimental design, accurate data interpretation, and informed decision-making.
• Contribute to advancing programs involving bioconjugates, oligonucleotides, bispecifics, and other therapeutic modalities.
• Explore and evaluate innovative bioanalytical technologies and emerging platforms to support an evolving portfolio, including novel molecular modalities and therapeutic areas.
• Document experiments, results, and findings in an electronic lab notebook.
• Present scientific work at internal and external meetings.
• Perform general lab and instrument maintenance.
• Grow into the role of bioanalytical representative on cross-functional project teams, effectively managing priorities to meet multiple project goals and timelines.

Requirements

• Degree in Chemistry, Biochemistry, Pharmaceutical Science, or a related discipline: B.S. with 10+ years, M.S. with 8+ years, or Ph.D. with 0-6 years postdoctoral experience.
• Proven expertise and extensive experience in liquid chromatography and mass spectrometry, with a demonstrated track record of successfully developing MS, LC-MS, or LC-MS/MS methods.
• Hands-on experience in sample preparation techniques (LLE, SPE, immunocapture, enzymatic digestion, homogenization, etc.) and automation platforms.
• Scientific curiosity and strong capabilities in experimental design, execution, data interpretation, and troubleshooting with limited supervision.
• Ability to think critically and prioritize and manage multiple projects under aggressive timelines in a fast-paced environment.
• Detail-oriented with good interpersonal, technical writing, and verbal communication skills.

Preferred Qualifications

• Industrial experience in bioanalysis of LC-MS–based small molecule, siRNA, biomarkers, and biotherapeutics assay development.
• Previous experience in a GLP lab and mass spectrometry applications in ADC analytics, metabolomics, and proteomics.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans.
• Equity awards.
• Pension or retirement benefits, 401(k) company match.
• Health and wellness programs, fitness centers.
• Insurance benefits (e.g., medical, dental, vision, life, and disability).
• Paid time off and family support benefits.

Pay

Salary Range (annually): $109,900.00 - $179,300.00.