Senior Scientist - Bioanalytical & Biomarker Technologies

About the role

We are seeking a highly motivated bioanalytical scientist to contribute to the development and implementation of state-of-the-art quantitative and qualitative analytical and bioanalytical methods supporting biopharmaceuticals in Regeneron’s discovery and preclinical development pipeline. The successful candidate will function well in a collaborative, fast-paced, multidisciplinary team environment.

Responsibilities

• Develop LC-MS–based bioanalytical methods in various biological matrices.
• Apply these methods to quantify biotherapeutic levels, assess in vitro stability, evaluate in vivo biotransformation, and measure biomarkers (small molecules, peptides, and proteins).
• Support characterization of drug candidates and critical reagents within the discovery pipeline.
• Collaborate closely with chemistry, conjugation, biology, PK, and TK teams to ensure strong experimental design, accurate data interpretation, and informed decision-making.
• Contribute to advancing programs involving bioconjugates, oligonucleotides, bispecifics, and other therapeutic modalities.
• Explore and evaluate innovative bioanalytical technologies and emerging platforms to support an evolving portfolio, including novel molecular modalities and therapeutic areas.
• Document experiments, results, and findings in an electronic lab notebook.
• Present scientific work at internal and external meetings.
• Perform general lab and instrument maintenance.
• Grow into the role of bioanalytical representative on cross-functional project teams, effectively managing priorities to meet multiple project goals and timelines.

Requirements

• Degree in Chemistry, Biochemistry, Pharmaceutical Science, or a related discipline: B.S. with 10+ years, M.S. with 8+ years, or Ph.D. with 0-6 years postdoctoral experience.
• Proven expertise and extensive experience in liquid chromatography and mass spectrometry, with a demonstrated track record of successfully developing MS, LC-MS, or LC-MS/MS methods.
• Hands-on experience in sample preparation techniques (LLE, SPE, immunocapture, enzymatic digestion, homogenization) and automation platforms.
• Scientific curiosity and strong capabilities in experimental design, execution, data interpretation, and troubleshooting with limited supervision.
• Ability to think critically and prioritize and manage multiple projects under aggressive timelines in a fast-paced environment.
• Detail-oriented with good interpersonal and effective technical writing and verbal communication skills.

Preferred Qualifications

• Industrial experience in bioanalysis of LC-MS–based small molecule, siRNA, biomarkers, and biotherapeutics assay development.
• Previous experience in a GLP lab and mass spectrometry applications in ADC analytics, metabolomics, and proteomics.

Job level may be adjusted based on experience.

Pay

Salary Range (annually): $109,900.00 - $179,300.00

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits, 401(k) company match
• Health and wellness programs, fitness centers
• Insurance benefits (e.g., medical, dental, vision, life, and disability)
• Paid time off
• Family support benefits

For additional information about Regeneron benefits in the U.S., visit Regeneron Total Rewards. For other locations, additional information will be provided during the recruitment process.

Schedule

This is a full-time, on-site role. Many roles at Regeneron are required to be performed on-site.

Location: Tarrytown, NY