Senior Scientist

Responsibilities

• Support and spearhead the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.
• Support the optimization of probe chemistry and probe-based sequencing with spatial multi-omic profiling applications.
• Help develop the optimization of sample preparation methods such as tissue/cell fixation and permeabilization in diverse tissue (FF and FFPE) and cell types.
• Independently plan and execute experiments, accurately record details, provide in-depth analysis, and report results through documentation and presentations.
• Aid/lead in the analysis of large and complex data sets, including developing routines for streamlined and automated data pipelines.
• Prepare assay reagents and other components.
• Work within multidisciplinary teams at all stages of product development.
• Assist with research projects to profile spatial genomics.
• Collaborate with other team members on research studies.
• Support and lead elements of the development, verification and validation of product related kits and reagents.
• Analyze specimens on imaging instrumentation.
• Analyze research data and assist with data interpretation.
• Interface directly with product development teams to transfer and optimize new technologies.
• Prepare research reports and share findings with the team.
• Write protocols, develop procedures, and maintain accurate records.
• Clearly communicate and present results; contribute data for making critical design decisions.

Qualifications

• PhD in biophysics, chemical/biomolecular engineering, molecular biology, biochemistry, cell biology, or a related field and 5+ years of hands-on molecular biology experience in an industrial setting.
• Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques.
• Experience with applying microscopy to answer biological problems.
• Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques.
• Understanding of basic absorption and emission spectroscopy.
• Highly motivated with excellent attention to detail.
• Good communication (oral and written) and collaboration skills.
• Experience in cell culture and tissue (FF and FFPE) preparation techniques.
• Experience in troubleshooting and optimization of molecular biology assays including reagent formulation and workflow optimization.
• Experience with experimental design and data analysis.
• Must be capable of performing complex multi-step experiments with detailed and diligent attention to technique and protocols with accurate record keeping.
• Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.

Additional Desirable Skills

• Experience with multiplexed, multiomic imaging technologies in tissues and cells.
• Experience in product development including product release.
• Familiarity with basic statistical data and error analysis.
• Familiarity with single cell and/or spatial transcriptomics, fixation chemistry, Design of Experiments (DOE).
• Advanced fluorescence imaging techniques.
• Experience in microscopy image analysis.
• Familiarity with different cell and tissue segmentation software and programs.
• Experience with use and troubleshooting of automated equipment, preferably for imaging applications.