Senior Scientist, Antibody Conjugation
About the role
We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies. This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material. You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies.
Responsibilities
- Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
- Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
- Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
- Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
- Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows