Senior Scientist, Protein and Antibody Bioconjugation

About the role

We seek a Bioconjugation Sr. Scientist to join our Bioconjugates Research Group. The successful candidate will contribute to the design, generation, and characterization of novel bioconjugate modalities, including antibody-peptide conjugates (APC), antibody-oligonucleotide conjugates (AOC), and antibody-drug conjugates (ADC).

Responsibilities

• Carry out laboratory functions, plan and design experiments, and apply technical knowledge and skills to achieve project goals in a precise and timely manner.
• Design, synthesize, and characterize antibody conjugates using state-of-the-art bioconjugation methods, purification processes, and biophysical techniques.
• Optimized conjugation protocols using novel chemistries and techniques for a variety of bioconjugates modalities such as peptide-antibody (APC), oligonucleotides-antibody (AOC) and small molecule antibody (ADC) conjugates.
• Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is desirable.
• Identify and troubleshoot critical issues within conjugation processes, resolving them promptly to ensure consistent progress and quality.
• Collaborate cross-functionally with chemists and other teams to design and establish linker-payload biologic SAR (structure-activity relationships), supporting scientific discovery and project progression.
• Tracks progress against the timelines of ongoing projects, ensuring timely delivery of results and providing regular updates to project teams and stakeholders.
• Effective communication of scientific rationale, results, and interpretation at project, team and departmental meetings, contributing to strategic discussions.
• Represent our function in cross-functional meetings and contributes to decision-making at the program level, driving strategy, execution, and delivery of critical milestones.
• Communicate scientific rationale, data, and interpretations effectively in project, team, and departmental meetings.
• Contribute to project and platform strategy, including proposing new technologies, approaches, or areas of exploration.

Requirements

• BS/BA degree in biology and 4+ years of relevant industry experience OR MS/MA degree in biology and 3+ years of relevant industry experience OR PhD or equivalent and some relevant experience.
• In-depth knowledge of modern protein bioconjugation (peptide, protein, and antibody) purification, and analytical characterization.
• Hands-on experience with antibody conjugates with various payload classes, including peptides, oligonucleotides, and small molecules.
• Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is an advantage.
• Strong background in analytical characterization of bioconjugates, specifically RP-HPLC, LC-MS.
• Proficiency in purification techniques for antibodies and antibody conjugates such as RP-HPLC, FPLC-AKTA, size-exclusion (SEC), ion exchange (IEX), tangential flow filtration (TFF).
• Independently design and implement conjugation and purification strategies applying stay-of-the-art knowledge in the field.
• Understanding of peptide, siRNA, and protein structure and associated biophysical techniques to assess structure, stability, and behavior in solution is desirable.
• Experience in formulation strategies for conjugate molecules is a plus.
• Excellent interpersonal skills with strong oral and written communication abilities.
• Able to meet multiple deadlines across various projects/programs with a high degree of accuracy and efficiency.
• High attention to detail and commitment to data integrity, reproducibility, and quality documentation.

Qualifications

• BS/BA degree in biology and 4+ years of relevant industry experience OR MS/MA degree in biology and 3+ years of relevant industry experience OR PhD or equivalent and some relevant experience.

Skills

• Strong publication record of accomplishment.
• Understanding of peptide, siRNA, and protein structure and associated biophysical techniques to assess structure, stability, and behavior in solution is desirable.
• Experience in formulation strategies for conjugate molecules is a plus.
• Excellent interpersonal skills with strong oral and written communication abilities.
• Able to meet multiple deadlines across various projects/programs with a high degree of accuracy and efficiency.
• High attention to detail and commitment to data integrity, reproducibility, and quality documentation.

Benefits

• Annual base salary: $110,800.00 - $151,000.00.
• Annual bonus with a target of 20% of the earned base salary.
• Eligibility to participate in our equity based long term incentive program.
• Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.