Senior Research Technician - Neurosurgery

About the role

The Senior Research Technician will provide technical support for translational immunology and neuro-oncology research focused on T-cell trafficking, tumor immunology, and CAR-T cell therapy for brain tumors. The researcher will perform and optimize complex laboratory procedures including tissue and blood processing, multiparameter flow cytometry, immunofluorescence and immunohistochemical staining, cell culture, CAR-T cell functional assays, cytokine analyses, molecular biology techniques, and animal tumor studies. Performs independently complex research studies, experiments and assays.

Primary Duties & Responsibilities

• Perform complex analysis/projects according to research protocols, explaining methods and procedures to other technicians.
• Process brain tumor and peripheral blood specimens.
• Perform flow cytometry, T-cell phenotyping, and functional immune assays.
• Conduct immunofluorescence, immunohistochemistry, and image analysis.
• Generate and evaluate CAR-T cells using in vitro cytotoxicity assays.
• Perform cytokine profiling, ELISA-based assays, and molecular biology workflows.
• Support murine brain tumor studies, including treatment administration and tissue collection.
• Ensure lab conditions and equipment are properly cleaned and maintained in accordance with established procedures.
• Maintain experimental datasets, perform basic statistical analyses, and ensure rigorous documentation.
• Assure compliance with established safety procedures and maintain required documentation on laboratory and specimen conditions.

Working Conditions

Works in a laboratory environment with potential exposure to biological and chemical hazards. Must be physically able to wear protective equipment and to provide standard care to research animals.

Education

Required Qualifications: Master’s degree or combination of education and/or experience may substitute for minimum education.

Skills

Not Applicable

More About This Job

WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.