Senior Research Associate, In Vivo Pharmacology

About the role

The Senior Research Associate, In Vivo Pharmacology at Thymmune Therapeutics will play a key role in advancing the company's thymic rejuvenation programs. This individual will conduct in vivo studies, perform comprehensive analytical assessments, and document all aspects of the research process.

Responsibilities

• Conduct in vivo studies and perform comprehensive analytical assessments to evaluate the efficacy and safety of iPSC-derived thymic cell therapies.
• Establish and execute animal models to support proof-of-concept and pharmacology studies.
• Perform standard dosing procedures (SC, IM, IV, IP) for cell administration, blood sampling techniques (submandibular bleeds and tail nick) for immune cell profiling, as well as tissue collection (e.g., lymph tissue, muscle, and major organs) via necropsy.
• Isolate cells from primary tissues and conduct downstream biological assays to evaluate cell quality and function, including Flow Cytometry (FACS), RT-qPCR/ ddPCR, MSD/ELISA, Immunofluorescence imaging.
• Maintain high standards of data integrity and ensure accurate, reproducible, and well-documented data to support reliable analysis and decision-making.
• Analyze complex datasets using statistical software (e.g., GraphPad Prism) and effectively present findings to the scientific team.
• Document in vitro and in vivo studies using electronic notebook (e.g., Benchling) to maintain detailed records of study design, experimental procedure, analytical data, and results.
• Lead study planning and organization, write study reports, and participate in the strategic planning of long-term studies.
• Develop and execute immunological assays (e.g., cell activation, cytotoxicity, mixed lymphocyte reaction) to assess the allo-reactivity and tolerance of immune cells.
• Conduct and/or assist with small rodent surgical procedures (e.g., tissue transplantation, cell implantation), experience in surgical procedures is a key asset.
• Maintain cell culture of cell line or primary immune cells using aseptic techniques.
• Ensure strict adherence to all Institutional Animal Care and Use Committee (IACUC) guidelines and standard operating procedures (SOPs) for animal welfare.
• Collaborate cross-functionally to support timely execution of in vivo studies to characterize and select candidate cell therapy product.

Requirements

• 5+ years of experience conducting in vivo pharmacology studies, including study execution, animal handling, dosing, sample collection, and tissue processing with a Bachelor's Degree in immunology, regenerative medicine, or a related life sciences discipline.
• 3+ years of experience conducting in vivo pharmacology studies, including study execution, animal handling, dosing, sample collection, and tissue processing with a Master's Degree in immunology, regenerative medicine, or a related life sciences discipline.
• Demonstrated proficiency in rodent handling, tissue collection/dissection, and multiple routes of administration, including intravenous (IV), intraperitoneal (IP), and subcutaneous (SC) injections, and tissue dissection is required.
• Strong experience with Flow Cytometry, qPCR, ELISA/MSD techniques. Demonstrated ability to analyze data, apply appropriate statistical methods, and independently troubleshoot experimental variability.
• Excellent oral and written communication skills. Must be able to structure tasks, set priorities, and work effectively in a collaborative, team-oriented environment.

Preferred Qualifications

• 1+ year of experience in the biotech and/or biopharma industry.
• Hands-on experience with the isolation, processing, and culture of primary human cells or tissues is preferred.
• Fundamental knowledge of thymus biology and immunology or demonstrated ability to rapidly acquire expertise in these areas, is preferred.

Pay

$79,000.00 - $105,000.00

Schedule

100% based onsite