Senior Manager, IT Infrastructure & Operations

About the role

F2G is a clinical‑stage biopharmaceutical company focused on discovering and developing novel therapies for life‑threatening invasive fungal infections. The company has created a new class of antifungal agents called the orotomides, which selectively target fungal dihydroorotate dehydrogenase (DHODH). Its lead candidate, olorofim (formerly F901318), has fungicidal activity against a broad range of mold infections, including rare and resistant molds. F2G completed a Phase 3 study comparing olorofim to AmBisome® followed by standard of care in patients with invasive fungal disease caused by Aspergillus species, receiving positive topline data in June 2026. Olorofim has orphan drug status from the EMA and FDA, plus FDA Qualified Infectious Disease Product (QIDP) designation and Breakthrough Therapy designation. Headquartered in the UK with subsidiaries in the US and Austria, F2G’s vision is to bring safe, convenient, and effective novel antifungal agents to market to address global unmet needs for therapies active against resistant and historically difficult‑to‑treat pathogens.

Responsibilities

• Serve as the primary IT point of contact for the site, providing responsive support and owning issues through resolution.
• Perform end‑user IT support: troubleshoot and resolve hardware (laptops, smartphones, tablets, peripherals, conference‑room AV), software, network, and connectivity issues.
• Manage Entra ID identities, user provisioning and offboarding.
• Maintain accurate Service Desk documentation.
• Own the end‑user device lifecycle across computers and mobile devices: procurement, inventory, shipping/returns, provisioning, configuration, support, patching, and retirement.
• Configure and maintain Microsoft Intune and Windows Autopilot for secure remote/zero‑touch provisioning of Windows devices.
• Manage the MDM platform used to enrol, configure, secure, and manage smartphones and tablets (including BYOD), ensuring endpoint compliance with F2G policies.
• Help maintain a secure and compliant IT environment: endpoint and mobile device security, identity and access controls, security policies, threat response, and compliance requirements.
• Contribute to continuous improvement of the technology stack by identifying opportunities to simplify, standardize, automate, and modernize systems; evaluate new technologies; recommend enhancements for scalability, user experience, security, resilience, and operational efficiency.
• Ensure continuous training and enablement through new‑hire IT onboarding and maintaining a knowledge base of how‑to guides and FAQs.
• Support Tier 1/2/3 and VIP support, coordinating with internal teams, MSPs, and vendors when escalation is required while maintaining ownership through resolution.
• Participate in access control, documentation, auditability, security, privacy, backup and recovery, business continuity, disaster recovery, and CSV/CSA activities where relevant.
• Support F2G’s transformational period by ensuring the IT environment is scalable, resilient, and inspection‑ready; strengthen business continuity, access controls, system documentation, change management, and support processes; partner with Quality and business functions on CSV/CSA and regulated systems where applicable.
• Work at least one day per week on‑site at the Princeton, NJ office (hybrid flexibility).
• Engage with the company’s LinkedIn community (https://www.linkedin.com/company/f2g/).

Requirements

• Bachelor’s degree in Computer Science, Engineering, Information Technology, or a related discipline, or equivalent relevant experience.
• Minimum 5 years of experience in IT support, systems administration, end‑user computing, or a related role.

Qualifications

• Hands‑on experience supporting Windows and mobile environments (laptops, smartphones, tablets, hardware troubleshooting, software configuration, network connectivity, peripherals, conference‑room technology).
• Experience with Microsoft Intune and Windows Autopilot for Windows endpoint management (remote/zero‑touch provisioning, application deployment, configuration and compliance policies, patching, device lifecycle management).
• Experience with MDM platforms for smartphones and tablets (device enrolment, configuration, security and compliance policies, application deployment, remote support, and device retirement/wipe).
• Experience with Microsoft 365, Entra ID, identity and access management, SSO/MFA, user provisioning and offboarding, endpoint protection, Azure, and related Microsoft technologies.
• Working knowledge of IT security, access control, data protection, endpoint security, and relevant compliance frameworks such as NIST, GDPR, HIPAA, SOX, and HITRUST.

Skills

• Strong troubleshooting and root‑cause analysis skills; ability to resolve issues quickly while implementing sustainable solutions that prevent recurrence.
• Experience documenting incidents and resolutions and building knowledgebase, how‑to, and self‑service content for users.
• Strong communication and customer‑service skills; ability to explain technical issues clearly to non‑technical users.
• Highly organized, self‑directed, and comfortable managing multiple priorities in a fast‑moving environment, including occasional out‑of‑hours support when required.