Senior Director, US Medical Affairs Strategy Lead, Gastrointestinal, Oncology and Emerging Indications

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, currently in clinical development.

About the role

Reporting to the VP US Medical Affairs Strategy Lead, the Senior Director, US Medical Affairs, will develop and execute the US Medical Affairs (USMA) strategy and tactical plans with a focus on launch readiness and life cycle management for an individual asset in gastrointestinal (GI) and emerging indications. The role involves collaborating with cross-functional teams in Development, Research, and Commercial to design and implement a comprehensive GI strategy.

Responsibilities

• Develop and execute the USMA strategy and medical objectives, including scientific engagement, communication, evidence generation, internal education, and patient advocacy.
• Create and implement a Health Care Professional (HCP) engagement strategy to gather insights and inform medical strategy.
• Serve as the US medical representative on cross-functional teams and as a therapeutic area content expert.
• Participate in the Global Medical Affairs Team (GMAT) and US Medical Affairs Team (USMAT) to execute medical strategies and support pre-launch activities.
• Conduct routine gap assessments to refine publication strategy, evidence generation plans, and tactical plans as part of the overall USMA plan.
• Provide medical leadership in scientific engagement activities, including advisory boards, investigator interactions, congress activities, and peer-to-peer discussions.
• Communicate clinical and scientific data to KOLs and healthcare professionals through presentations, educational programs, and scientific discussions.
• Represent Medical Affairs in cross-functional strategy meetings, including Clinical, Safety, Global Brand Team, Patient Advocacy, and Market Access.
• Support the Clinical and US MSL teams to ensure clinical trials meet study timelines through enrollment, scientific, and engagement support.
• Partner with RWE strategy and Biomarker/CDx teams on integrated evidence generation strategies.
• Work with Patient Advocacy and Grants teams to incorporate the patient voice and define external medical education strategies.
• Provide medical support for congresses and collaborate across US and Global functions to develop and align key scientific communication points and medical information response documents within legal and compliance guidelines.
• Support the review and approval of abstracts, manuscripts, corporate communications, and internal stakeholder medical education activities.
• Collaborate with stakeholders across Clinical Development, Commercial Operations, Program Management, Business Development, Regulatory, Safety, and Compliance teams.

Requirements

• Advanced doctorate degree (PharmD, PhD, MD, DO or equivalent) in a medical or scientific area.
• 15+ years of relevant experience in the biotech or pharmaceutical industry, with a focus on Medical Affairs, including cross-functional headquarters and field-based team experience.
• Strong scientific background in GI cancer, with expertise in biomarker-driven disease and the ability to analyze, synthesize, and communicate complex scientific information.
• Direct experience executing activities within medical affairs, such as training, medical communications, medical information, expanded access programs, evidence generation, and publications.
• Proven track record of clinical trial support, including protocol development/review, site selection, enrollment support, and data analysis.
• Excellent interpersonal, written, and presentation skills, with the ability to communicate complex scientific data to diverse audiences.
• Ability to thrive in a fast-paced, dynamic environment and manage multiple tasks independently with limited supervision.
• Willingness to travel to Redwood City headquarters and professional congresses (30-40%).
• Strong networking skills and deep existing relationships with GI cancer healthcare professionals, including US top key opinion leaders.

Preferred Qualifications

• Experience in US product launches, including support for integrated brand plan ideation, regulatory submissions, reimbursement, and label development.
• Experience in guideline submissions (e.g., NCCN) and engagements with US clinical practice guidelines.

Pay

The base pay salary range for this full-time position at our headquarters in Redwood City, CA is $232,000 - $290,000 USD. The range may be adjusted for the local market if the candidate is based outside Redwood City. Individual base pay is determined by job-related skills, experience, market dynamics, and relevant education or training.

Benefits

Revolution Medicines offers competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities as part of its total rewards program.