Senior Director, Translational Medicine and Clinical Biomarkers

About the role

Own the translational science that decides which patients get treated and how — leading biomarker strategy across Nurix’s entire oncology and immunology portfolio. This is a senior, portfolio-level role with direct influence on trial design, dosing decisions, and executive strategy from day one. Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Location: Onsite – Brisbane, CA.

Responsibilities

• Own and evolve the clinical biomarker strategy across Nurix's full clinical portfolio, setting priorities that inform patient stratification, response prediction, and resistance mechanisms for multiple concurrent programs.
• Provide scientific interpretation of biomarker data, informed by a strong understanding of cell and tumor biology, molecular biology, inflammation, and immuno-oncology, helping translate those insights into patient-selection, dose-selection, go/no-go, and program-level development decisions.
• Direct the build-out and governance of biomarker assay capabilities across the portfolio, including assay qualification standards, platform strategy, and vendor/CRO oversight, to ensure consistent, scalable execution across programs rather than one-off, program-specific solutions.
• Set the strategic direction for evaluation and adoption of novel biomarker technologies and platforms, positioning Nurix's biomarker capabilities ahead of program needs rather than reacting to them.
• Lead and integrate cross-functional, matrixed teams