Senior Director, Translational Biology

We need to output HTML fragment with sections: About the role? The posting includes Job Summary, Key Responsibilities (with subheadings: Translational Research Strategy, Biomarker and Clinical Translation, Scientific Leadership, Team Leadership and Management), Qualifications (Required, Preferred, Competencies), Pay (salary range), Benefits (Company benefits). Also maybe Schedule? Not present. So we include sections with real content: About the role (maybe from Job Summary). Responsibilities (list). Qualifications (list). Benefits (list). Pay (maybe a paragraph). Ensure we don't include boilerplate like application deadline, disclaimer, EEO, scam warning, etc. Also remove duplicated lines. Must preserve all substantive info. We need to use

for section headings. Use

• for any list of duties/requirements/benefits. Use

  for prose. We must not repeat job title as heading. No Job ID. We must not create sections with filler like "commensurate with experience". Pay section: we have salary range; we can include that. Benefits: list. We need to preserve all substantive info: Job Summary paragraph, responsibilities details, qualifications required/preferred, competencies, pay range, benefits list. We should not include "Application Deadline", "Company benefits:" maybe we keep benefits but not the phrase "Company benefits:" as heading? We'll make a Benefits section with list. We need to ensure we don't include navigation/legal/EEO etc. So remove all that. Let's extract content. Job Summary: "The Senior Director of Translational Biology will lead the development and execution of translational biology research strategies across the drug discovery and development pipeline. This individual will serve as a key scientific leader responsible for translating biological insights into clinical hypotheses, biomarker strategies, patient selection approaches, and proof-of-mechanism frameworks that support successful advancement of therapeutic programs. Working closely with Discovery Research, Clinical Development, Bioinformatics, Biomarker Sciences, Quantitative Sciences, and Regulatory teams, the successful candidate will integrate preclinical and clinical data to drive data-informed decisions and enable precision medicine strategies and development of disease biomarkers enabling early go no go decisions. As an industry-leading expert and trusted advisor to senior leadership, this leader directs complex, cross-functional initiatives with enterprise impact, and helps define the operating model and culture of discovery groups as well as OPDC." Key Responsibilities: subheadings: - Translational Research Strategy: bullet points? The text: "Develop and implement translational biology strategies from target validation through clinical development in collaboration with discovery groups Establish mechanistic understanding of disease biology and therapeutic interventions to support program progression and development of disease biomarkers across portfolio of assets. Support discovery groups as well as early development organization with translational endpoints, biomarkers, and pharmacodynamic measures that inform decision-making. Integrate multi-omics, biomarker, and clinical data to generate actionable insights in collaboration with biomarkers and discovery groups. Lead development of patient stratification and precision medicine approaches." - Biomarker and Clinical Translation: "Design and oversee disease biomarker discovery, validation, and implementation in discovery and development organizations. Partner with Clinical Development teams to support first-in-human and proof-of-concept studies. Support definition of pharmacodynamic, predictive, prognostic, and response biomarkers. Support clinical data interpretation and translational analyses." - Scientific Leadership: "Serve as translational biology lead for one or more therapeutic programs. Provide scientific guidance to cross-functional project teams and senior leadership. Identify emerging technologies and scientific opportunities that enhance translational capabilities. Represent the company at scientific conferences, investigator meetings, and external collaborations. Build and maintain relationships with academic investigators, CROs, and strategic partners." - Team Leadership and Management: "Recruit, mentor, and develop high-performing translational scientists. Foster a collaborative and innovative scientific culture. Manage departmental resources, budgets, and external partnerships. Establish operational processes and best practices for translational research activities." Qualifications: Required: "MD, PhD, or MD/PhD with subspecialty training Translational Biology, Physiology and Translational Medicine strongly preferred. 10–15+ years of Translational Biology, single-cell technologies, spatial biology, and AI-enabled translational research approaches. Recognized thought leader with scientific contributions (publications, presentations); expert understanding of industry best practices and adjacent functional areas. Proven success leading complex, cross-functional teams in a matrixed, global environment; exceptional strategic thinking and decision-making under uncertainty. Outstanding communication skills with the ability to synthesize complex data and influence executive stakeholders." Preferred: "Deep expertise in CNS, neurology, neuroimmunology, psychiatry, neurodegenerative disease, and neuroinflammation. Experience implementing clinical study plans to drive decision-making. Experience with external collaborations, including collaborative animal model experiments, key opinion leader interactions and advisory boards. Prior experience building or scaling early development operating models and ways of working." Competencies: list of bullet points: "Accountability for Results - Stay focused on key strategic objectives, be accountable for high standards of performance, and take an active role in leading change. Strategic Thinking & Problem Solving - Make decisions considering the long-term impact to customers, patients, employees, and the business. Patient & Customer Centricity - Maintain an ongoing focus on the needs of our customers and/or key stakeholders. Impactful Communication - Communicate with logic, clarity, and respect. Influence at all levels to achieve the best results for Otsuka. Respectful Collaboration - Seek and value others’ perspectives and strive for diverse partnerships to enhance work toward common goals. Empowered Development - Play an active role in professional development as a business imperative." Pay: "Minimum $230,720.00 - Maximum $345,000.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate’s job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws." Benefits: "Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits." We should not include the link or "Come discover more about Otsuka..." etc. Now produce HTML. Structure:

  About the Role

  Job Summary paragraph.

  Responsibilities

  • Translational Research Strategy: ...
  ... etc. But we need to decide if we should keep subheadings inside li or separate headings? The instruction: use

  for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). Use

  • for any list of duties/requirements/benefits, and

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    of items. Each item can be a sentence. We can embed the subheadings as part of the li text. Similarly Qualifications: we can have Required and Preferred as separate sub-sections? Could be separate

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        About the Role

        The Senior Director of Translational Biology will lead the development and execution of translational biology research strategies across the drug discovery and development pipeline. This individual will serve as a key scientific leader responsible for translating biological insights into clinical hypotheses, biomarker strategies, patient selection approaches, and proof-of-mechanism frameworks that support successful advancement of therapeutic programs. Working closely with Discovery Research, Clinical Development, Bioinformatics, Biomarker Sciences, Quantitative Sciences, and Regulatory teams, the successful candidate will integrate preclinical and clinical data to drive data-informed decisions and enable precision medicine strategies and development of disease biomarkers enabling early go no go decisions. As an industry-leading expert and trusted advisor to senior leadership, this leader directs complex, cross-functional initiatives with enterprise impact, and helps define the operating model and culture of discovery groups as well as OPDC.

        Responsibilities

        • Translational Research Strategy: Develop and implement translational biology strategies from target validation through clinical development in collaboration with discovery groups; establish mechanistic understanding of disease biology and therapeutic interventions to support program progression and development of disease biomarkers across portfolio of assets; support discovery groups as well as early development organization with translational endpoints, biomarkers, and pharmacodynamic measures that inform decision-making; integrate multi-omics, biomarker, and clinical data to generate actionable insights in collaboration with biomarkers and discovery groups; lead development of patient stratification and precision medicine approaches.
        • Biomarker and Clinical Translation: Design and oversee disease biomarker discovery, validation, and implementation in discovery and development organizations; partner with Clinical Development teams to support first-in-human and proof-of-concept studies; support definition of pharmacodynamic, predictive, prognostic, and response biomarkers; support clinical data interpretation and translational analyses.
        • Scientific Leadership: Serve as translational biology lead for one or more therapeutic programs; provide scientific guidance to cross-functional project teams and senior leadership; identify emerging technologies and scientific opportunities that enhance translational capabilities; represent the company at scientific conferences, investigator meetings, and external collaborations; build and maintain relationships with academic investigators, CROs, and strategic partners.
        • Team Leadership and Management: Recruit, mentor, and develop high-performing translational scientists; foster a collaborative and innovative scientific culture; manage departmental resources, budgets, and external partnerships; establish operational processes and best practices for translational research activities.

        Qualifications

        Required

        • MD, PhD, or MD/PhD with subspecialty training; Translational Biology, Physiology and Translational Medicine strongly preferred.
        • 10–15+ years of Translational Biology, single-cell technologies, spatial biology, and AI-enabled translational research approaches.
        • Recognized thought leader with scientific contributions (publications, presentations); expert understanding of industry best practices and adjacent functional areas.
        • Proven success leading complex, cross-functional teams in a matrixed, global environment; exceptional strategic thinking and decision-making under uncertainty.