Senior Director of Clinical Science - Hematology

About the Role

The Senior Director, Clinical Science – Hematology provides strategic Clinical Science leadership across the hematology disease area, with accountability spanning multiple studies, programs, and assets. This role contributes to disease area strategy by applying deep therapeutic expertise to guide Clinical Science approaches, support development planning, and promote consistency in scientific standards, medical data review practices, and decision-making across the portfolio.

The Senior Director partners closely with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional development team members to support study planning, data interpretation, issue resolution, and broader program decisions. This role has a strong strategic orientation and shapes how Clinical Science work is performed across the hematology portfolio, including standardization of practices and alignment of scientific approaches. The Senior Director may also provide direct management and development of multiple Clinical Scientists.

Responsibilities

• Provide strategic Clinical Science leadership across the hematology disease area, including multiple studies, programs, and assets.
• Contribute to disease area strategy by providing Clinical Science input on development opportunities, scientific considerations, portfolio risks, and implications of emerging data.
• Partner with cross-functional leaders to align Clinical Science activities with broader program and disease area objectives.
• Apply expert knowledge of hematologic cancers, disease biology, treatment landscape, and clinically meaningful endpoints to inform study planning, data interpretation, and issue resolution.
• Support cross-study and cross-asset integration of scientific insights to inform development decisions.
• Lead efforts to standardize Clinical Science approaches, including medical data review practices, data interpretation principles, and key deliverables.
• Promote consistency in Clinical Science activities while allowing for program-specific needs.
• Establish and maintain standards, expectations, and leading practices for Clinical Science work within the hematology portfolio.
• Provide senior scientific guidance across assigned studies and programs to ensure high-quality and consistent Clinical Science input.
• Guide interpretation of clinical data to support understanding of trends, opportunities, risks, and program implications.
• Support identification and evaluation of clinical, scientific, and data-related issues for cross-functional and governance discussions.
• Contribute scientific perspective to protocol development, amendments, study design, endpoint selection, eligibility criteria, and biomarker strategy.
• Serve as a Clinical Science subject matter resource for hematology across study teams and partner functions.
• Contribute Clinical Science perspective to portfolio discussions, governance reviews, and senior leadership meetings.
• Support preparation of clinical and scientific content for governance discussions and senior management communications.
• Present cross-study insights, scientific assessments, and key issues to cross-functional leaders and governance bodies.
• Provide direct management for Directors, Principal Scientists, and Clinical Scientists, including setting expectations and supporting development.
• Foster a culture of accountability, inclusion, continuous learning, and strong team performance.
• Partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Data Management, Drug Safety, Translational Medicine, Medical Affairs, and other key functions.
• Represent Clinical Science in cross-functional planning, program discussions, and strategic decision-making forums.
• Ensure Clinical Science activities comply with regulatory requirements, company policies, and established procedures.
• Support inspection readiness and appropriate documentation of Clinical Science contributions.
• Identify opportunities to improve the quality, consistency, and effectiveness of Clinical Science work.
• Maintain awareness of relevant scientific, clinical, and regulatory developments in hematologic cancers.

Qualifications

Advanced scientific or healthcare degree required (PhD, PharmD) with at least 7 years of hematological oncology drug development experience, or Master’s Degree in life sciences with 12 years of hematological oncology drug development experience.

Experience

• Significant experience in Clinical Development, Clinical Science, oncology development, or a related function within the pharmaceutical or biotechnology industry.
• Demonstrated experience providing Clinical Science leadership across multiple studies, programs, or assets.
• Deep therapeutic area expertise in hematologic cancers, including disease biology, treatment landscape, clinically relevant endpoints, and key scientific considerations.
• Strong understanding of clinical trial design, clinical development strategy, clinical data review, and interpretation of oncology data.
• Experience contributing to disease area strategy, portfolio discussions, or cross-program planning.
• Experience contributing to regulatory submissions, safety reviews, or health authority interactions.
• Experience working effectively in cross-functional teams within a matrix environment.
• Demonstrated ability to integrate information across studies and programs to support scientific and business decisions.
• Excellent communication, influence, and executive presentation skills.
• Demonstrated people leadership experience, including management, coaching, and development of scientific staff.

Skills

• Change Agility
• Clinical Development
• Clinical Oncology
• Clinical Reporting
• Clinical Research
• Clinical Sciences
• Clinical Study Management
• Clinical Trial Management
• Hematology
• Medical Sciences
• Oncology
• People Leadership
• Scientific Literacy

Schedule

Travel requirements: 0-25%