Senior Director of Clinical Science - Hematology

About the role

The Senior Director, Clinical Science – Hematology provides strategic Clinical Science leadership across the hematology disease area, with accountability spanning multiple studies, programs, and assets. Reporting to the Executive Director – Hematology, Oncology Assets and Early Development or the Head of Clinical Science Oncology, this role contributes to disease area strategy by applying deep therapeutic expertise to guide Clinical Science approaches, support development planning, and promote consistency in scientific standards, medical data review practices, and decision-making across the portfolio.

The individual partners closely with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional development team members to support study planning, data interpretation, issue resolution, and broader program decisions. This role has a strong strategic orientation and shapes how Clinical Science work is performed across the hematology portfolio, including standardization of practices, alignment of scientific approaches, and integration of insights across assets. The Senior Director may directly manage and develop multiple Clinical Scientists and provides leadership, coaching, and clear direction within a matrix environment.

Responsibilities

• Disease Area and Clinical Science Strategy
  • Provide strategic Clinical Science leadership across the hematology disease area, including multiple studies, programs, and assets.
  • Contribute to disease area strategy by providing Clinical Science input on development opportunities, scientific considerations, portfolio risks, and implications of emerging internal and external data.
  • Partner with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional leaders to align Clinical Science activities with broader program and disease area objectives.
  • Apply expert knowledge of hematologic cancers, disease biology, treatment landscape, and clinically meaningful endpoints to inform study planning, data interpretation, and issue resolution.
  • Support cross-study and cross-asset integration of scientific insights to inform development decisions within the hematology portfolio.
• Standardization and Scientific Consistency
  • Lead efforts to standardize Clinical Science approaches across the hematology disease area, including medical data review practices, data interpretation principles, and key deliverables.
  • Promote consistency in how Clinical Science activities are conducted across studies and programs while allowing for program-specific needs.
  • Help establish and maintain standards, expectations, and leading practices for Clinical Science work within the hematology portfolio.
  • Support alignment across assets on important disease area considerations, including endpoint interpretation, patient population considerations, safety topics, and emerging scientific issues.
  • Advocate for implementation of innovative approaches, including visual analytics, centralized data review, AI-enabled workflows, and other technologies that improve quality and efficiency.
• Strategic Scientific Leadership
  • Provide senior scientific guidance across assigned studies and programs to support high-quality and consistent Clinical Science input.
  • Guide interpretation of clinical data across studies, cohorts, and assets to support broader understanding of trends, opportunities, risks, and program implications.
  • Support identification and evaluation of important clinical, scientific, and data-related issues and ensure they are appropriately framed for cross-functional and governance discussions.
  • Contribute scientific perspective to protocol development, protocol amendments, study design considerations, endpoint selection, eligibility criteria, biomarker strategy discussions, and other development planning activities.
  • Serve as a Clinical Science subject matter resource for hematology across study teams and partner functions.
• Portfolio and Governance Contribution
  • Contribute Clinical Science perspective to portfolio discussions, governance reviews, and senior leadership meetings within the hematology disease area.
  • Support preparation of clinical and scientific content for governance discussions, program reviews, and senior management communications.
  • Present cross-study insights, scientific assessments, and key issues to cross-functional leaders and governance bodies, as appropriate.
  • Help ensure that portfolio and governance discussions are informed by sound scientific judgment and clinically meaningful interpretation of available data.
  • Translate portfolio priorities into Clinical Science strategies, capabilities, and resource plans.
• People Leadership and Capability Building
  • Provide direct management for Directors, Principal Scientists, and Clinical Scientists, as appropriate.
  • Set clear expectations for scientific quality, strategic thinking, collaboration, and effective communication.
  • Support development of Clinical Science talent through coaching, mentoring, feedback, and creation of development opportunities.
  • Promote consistency in role expectations and ways of working across Clinical Scientists supporting the hematology portfolio.
  • Foster a culture of accountability, inclusion, continuous learning, and strong team performance.
• Cross-Functional Leadership
  • Partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Data Management, Drug Safety and Pharmacovigilance, Translational Medicine, Medical Affairs, and other key partner functions.
  • Represent Clinical Science in cross-functional planning, program discussions, and strategic decision-making forums.
  • Facilitate alignment across studies, programs, and functions to support consistent scientific approaches and effective portfolio execution.
  • Support clear communication of clinical and scientific issues to relevant stakeholders and leadership teams.
• Compliance and Continuous Improvement
  • Ensure Clinical Science activities are conducted in accordance with applicable regulatory requirements, company policies, and established procedures.
  • Support inspection readiness and appropriate documentation of Clinical Science contributions, as applicable.
  • Identify opportunities to improve the quality, consistency, and effectiveness of Clinical Science work across the hematology disease area.
  • Maintain awareness of relevant scientific, clinical, and regulatory developments in hematologic cancers to inform disease area strategy and Clinical Science practices.

Core Leadership Skills

• Sets clear direction aligned with business and organizational priorities.
• Demonstrates strong scientific and strategic judgment in complex and ambiguous situations.
• Builds strong, collaborative relationships across functions and levels.
• Develops people through coaching, feedback, and support for growth.
• Creates an inclusive environment where perspectives are valued.
• Drives accountability and high standards for quality and performance.
• Communicates clearly and effectively with team members, cross-functional partners, and senior leaders.
• Leads through influence in a matrix environment and helps teams align around shared goals.
• Encourages continuous improvement, learning, and thoughtful challenge.
• Balances enterprise thinking with practical decision-making and timely action.

Qualifications

• Advanced scientific or healthcare degree required (PhD, PharmD) plus at least 7 years of hematological oncology drug development experience or Master’s Degree in life sciences plus 12 years of hematological oncology drug development experience.
• Significant experience in Clinical Development, Clinical Science, oncology development, or a related function within the pharmaceutical or biotechnology industry.
• Demonstrated experience providing Clinical Science leadership across multiple studies, programs, or assets.
• Deep therapeutic area expertise in hematologic cancers, including strong understanding of disease biology, current and emerging treatment landscape, clinically relevant endpoints, and key scientific considerations affecting development.
• Strong understanding of clinical trial design, clinical development strategy, clinical data review, and interpretation of oncology data.
• Experience contributing to disease area strategy, portfolio discussions, or cross-program planning.
• Experience contributing to regulatory submissions, safety reviews, or health authority interactions.
• Experience working effectively in cross-functional teams within a matrix environment.
• Demonstrated ability to integrate information across studies and programs to support scientific and business decisions.
• Excellent communication, influence, and executive presentation skills.
• Demonstrated people leadership experience, including management, coaching, and development of scientific staff.

Skills

• Required: Change Agility, Clinical Development, Clinical Oncology, Clinical Reporting, Clinical Research, Clinical Sciences, Clinical Study Management, Clinical Trial Management, Hematology, Medical Sciences, Oncology, People Leadership, Scientific Literacy.
• Preferred: Experience with visual analytics, centralized data review, or AI-enabled workflows.

Travel

0-25% travel required.

Pay

The salary range for this role is $190,800.00 - $300,300.00. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

Comprehensive package of benefits including medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, and additional programs as applicable.