Senior Director, Delivery

Responsibilities

• Lead and grow Sail’s Delivery team, advancing lipid nanoparticle (LNP) and targeted delivery technologies.
• Drive innovation in targeted nanoparticles, including design, formulation, ligand selection and conjugation, receptor-mediated uptake, and cytosolic delivery.
• Define and execute delivery strategy across tissues and disease areas, guiding nanoparticle engineering for precise targeting and biodistribution.
• Develop and apply high-throughput screening approaches to evaluate delivery performance, including biodistribution, cellular uptake, and functional expression.
• Partner with Program teams to advance multiple development candidates, improving efficiency, specificity, and translatability.
• Partner with Technical Development to ensure scalable, robust processes supporting progression to clinic.

Cross-Functional & Operational Leadership

• Lead cross-functional delivery efforts to advance programs from concept through candidate nomination.
• Collaborate with ligand design and program teams to align delivery strategies with disease biology and therapeutic goals.
• Identify and mitigate key delivery risks to enable program success.
• Drive integrated planning across delivery activities, aligning timelines, milestones, and resources.
• Manage external collaborations, including CROs and technology partners.
• Advise senior leadership on delivery strategy, portfolio prioritization, and execution risks.

Qualifications

• PhD or MD in drug delivery, chemical engineering, materials science, pharmaceutical sciences, or a related discipline with 12+ years of relevant industry experience.
• Deep expertise in lipid nanoparticle (LNP) systems, including formulation development, lipid chemistry, and in vitro/in vivo evaluation of delivery performance.
• Demonstrated experience in targeted delivery approaches, including ligand conjugation, receptor-mediated targeting, and nanoparticle surface engineering.
• Strong understanding of nucleic acid delivery challenges, including biodistribution, cellular uptake, endosomal escape, and immunogenicity.
• Experience advancing delivery technologies toward IND-enabling studies or clinical translation, with an appreciation for scalability, manufacturability, and regulatory considerations.
• Proven track record of advancing delivery technologies from discovery through preclinical development.
• Experience building and leading multidisciplinary scientific teams in a fast-paced biotech environment.
• Ability to operate strategically while remaining deeply connected to scientific detail and execution.
• Strong cross-functional leadership skills, with experience working across chemistry, biology, process development, and translational teams.
• Excellent communication skills, with the ability to influence senior stakeholders and clearly articulate complex technical concepts.

Pay

Salary Range: $235,000 - $290,000

Benefits

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.