Senior Associate Scientist, Translational Research, Oncology

About the role

The Protein Homeostasis Research Center (TRC) at Bristol Myers Squibb is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The TRC focuses on exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics.

Responsibilities

• Conduct full time laboratory-based research supporting translational research experiments in the context of preclinical and early-phase clinical trials.
• Participate on cross-site, cross-functional, and geographically diverse teams.
• Work with translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data.
• Select, validate, and deploy novel clinical-stage assays and analyses of data to accelerate development and provide insight into disease biology and drug mechanisms.
• Execute experiments to test hypotheses from clinical observations in preclinical model systems.
• Review scientific papers/protocols and apply appropriately to project needs.
• Help execute collaborative projects with leading academic and commercial research groups worldwide.

Requirements

A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful.

Qualifications

• Bachelor’s Degree in a scientific discipline with at least 4 years of work experience, or
• Master’s Degree in a scientific discipline with at least 2 years of work experience, preferably in industry and cancer biology.

Preferred Qualifications

• Hands-on experience with various in-vitro cellular and biochemical assays, including: 2D/3D cell culture (BSL2+), in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays), in-vivo sample processing (xenografts and other specimens), RNA analyses (e.g., qPCR, Nanostring), protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy).
• Familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq.
• Data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO).
• Proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation.
• Attention to detail with excellent organizational and record keeping skills.
• Excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally.
• Familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation.
• Ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner.
• Ability to handle multiple projects and work in a fast-paced dynamic team environment.
• Initiative, responsibility, and flexibility to adapt to changes with a positive attitude.

Benefits

Read more: careers.bms.com/working-with-us.