Senior Associate Scientist, Translational Research, Oncology

About the role

The Protein Homeostasis Research Center (TRC) at Bristol Myers Squibb is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The TRC focuses on exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics.

Responsibilities

• Conduct full time laboratory-based research supporting translational research experiments in the context of preclinical and early-phase clinical trials.
• Participate on cross-site, cross-functional, and geographically diverse teams.
• Work with translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data.
• Execute experiments to test hypotheses from clinical observations in preclinical model systems.
• Review scientific papers/protocols and apply appropriately to project needs.
• Help execute collaborative projects with leading academic and commercial research groups worldwide.

Requirements

• A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability.
• Highly motivated, collaborative, and creative.
• Self-starter and team player who can effectively collaborate with colleagues in the protein homeostasis, oncology, protein engineering/antibody development, chemistry, biomarker, and clinical groups.
• Proven track record in a relevant scientific area and strong technical skills.
• Clear and professional verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Qualifications

• Bachelor’s Degree in a scientific discipline with at least 4 years of work experience, or Master’s Degree with at least 2 years of work experience, preferably in industry and cancer biology.
• Hands-on experience with various in-vitro cellular and biochemical assays, including: 2D/3D cell culture (BSL2+), in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays), in-vivo sample processing (xenografts and other specimens), RNA analyses (e.g., qPCR, Nanostring), protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy), familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq, aptitude in experimental design, execution, data analysis and troubleshooting, data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO), proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation, attention to detail with excellent organizational and record keeping skills, excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally, familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation, ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner, ability to handle multiple projects and work in a fast-paced dynamic team environment, initiative, responsibility, and flexibility to adapt to changes with a positive attitude.

Skills

• Hands-on experience with various in-vitro cellular and biochemical assays, including: 2D/3D cell culture (BSL2+), in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays), in-vivo sample processing (xenografts and other specimens), RNA analyses (e.g., qPCR, Nanostring), protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy), familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq, aptitude in experimental design, execution, data analysis and troubleshooting, data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO), proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation, attention to detail with excellent organizational and record keeping skills, excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally, familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation, ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner, ability to handle multiple projects and work in a fast-paced dynamic team environment, initiative, responsibility, and flexibility to adapt to changes with a positive attitude.

Benefits

Read more: careers.bms.com/working-with-us.

Compensation Overview: Brisbane - CA - US: $107,240 - $129,945. The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life Benefits Include Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Responsibilities BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People With Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to the hiring process will be sent to the email address provided in your application. Thank you for your interest in BMS!