Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

About the role

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR-T or TCR T cells) from both early discovery programs as well as late-stage development programs' nonclinical studies that support regulatory submissions.

Responsibilities

• Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
• Characterizing genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)
• Developing and performing immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics
• Designing experiments independently and contributing to the project direction
• Maintaining an electronic lab notebook and documenting experiment results
• Reviewing and presenting research data to the functional team

Requirements

• BS/MS in immunology, cell biology or related field and 3+ years of relevant experience
• Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes
• Experience working on in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA and cytotoxicity assays
• Experience with gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation
• Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA-Seq

Qualifications

• Can-do attitude, curious, and excels in creative problem solving
• Multi-tasks and manages time well
• Quickly adapts to new research areas and implements new techniques independently
• Scientifically rigorous, highly organized, and self-started with excellent attention to detail
• Strong verbal and written communication skills
• Self-motivated and enthusiastic about working in an interdisciplinary, collaborative research environment

Benefits

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit here. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter. Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about on-site expectations for your role and location.