Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

About the role

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR-T or TCR T cells) from both early discovery programs as well as late-stage development programs' nonclinical studies that support regulatory submissions.

Responsibilities

• Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications

• Characterizing genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)

• Developing and performing immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics

• Designing experiments independently and contributing to the project direction

• Maintaining an electronic lab notebook and documenting experiment results

• Reviewing and presenting research data to the functional team

Requirements

• At least a BS/MS in immunology, cell biology or related field and 3+ years of relevant experience

• Experience working in a biotech/pharmaceutical industry

• Strong understanding of immunology and cancer biology

• Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes

• Experience working on in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA and cytotoxicity assays

• Gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation a plus

• Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA-Seq also advantageous

Qualifications

• Can-do attitude, curious, and excels in creative problem solving

• Multi-tasks and manages time well

• Quickly adapts to new research areas and implements new techniques independently

• Scientifically rigorous, highly organized, and self-starter with excellent attention to detail

• Strong verbal and written communication skills

• Self-motivated and enthusiastic about working in an interdisciplinary, collaborative research environment