Senior Associate Scientist, Delivery Technology
We are seeking a motivated and skilled Senior Associate Scientist to join our innovative targeted delivery team in Cambridge, MA. This onsite, lab-based role offers an excellent opportunity to work with cutting-edge technologies and contribute to the development of novel therapeutics in a dynamic and collaborative research environment.
About Alnylam
We are the leader in RNAi therapeutics—a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered breakthroughs that made RNAi therapeutics possible. Our deep pipeline, late-stage programs, and bold vision reflect core values: fierce innovation, passion for excellence, purposeful urgency, open culture, and commitment to people.
Responsibilities
- Support ligand discovery campaigns by executing key experiments for ligand discovery, screening, and characterization under the guidance of project leads.
- Perform high-throughput screening and selection using cell-based assays.
- Execute Next-Generation Sequencing (NGS) workflows, including library preparation from single cells.
- Perform standard molecular biology techniques, including PCR, plasmid preparation, and cloning.
- Run and assist in the development of automated, high-throughput screening assays to characterize ligand properties such as affinity, specificity, and internalization.
- Maintain detailed and accurate records of all experimental work and data in electronic lab notebooks.
- Collaborate closely with other members of the cross-functional team to ensure project goals are met.
- Assist in data analysis, interpretation, and the preparation of presentations for internal meetings.
Requirements
- BS/MS in Biology, Cell/Molecular Biology, or related field with 3-6 years of work experience, preferably in an industrial setting.
- Familiarity with flow cytometry and NGS library preparation is required.
- Hands-on experience with standard molecular biology techniques (e.g., PCR, cloning, DNA/RNA extraction) is required.
- Experience with mammalian cell culture and cell-based assays is highly desirable.
- Direct experience with single B cell isolation and screening technologies is a significant plus.
Pay
U.S. Pay Range: $80,000.00 - $120,000.00. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Benefits
- Comprehensive medical, dental, and vision coverage.
- Life and disability insurance.
- Lifestyle reimbursement program.
- Flexible spending and health savings accounts.
- 401(k) with a generous company match.
- Paid time off, wellness days, holidays, and two company-wide recharge breaks.
- Generous family resources and leave.