Jobs · Analyst · Massachusetts

Senior Analytical Chemist - Solid State Characterization

Sanofi · Cambridge, MA · 2 days ago
AnalystFull-time

Main Responsibilities

Lead and perform polymorphism studies for synthetics molecules, including polymorph screening, in depth physical characterization and thermodynamic assessment.
Design and conduct salt selection studies (salt screening, in depth physical characterization and stability assessment, …)
Act as the solid-state representative on development projects to deploy solid-form selection strategy in collaboration with other functions (e.g., Crystallization, Biopharm and Chemistry)
Develop and implement analytical methods using equipment including XRPD, DSC, TGA, SEM, Raman, IR, and laser granulometry
Provide physical characterization support (e.g, XRPD, PDS, etc) to internal partner teams
Use computational tools to perform Crystal Structure Prediction studies
Generate technical reports independently
Develop effective collaborations with others within project teams and between analytical groups
Introduce innovative analytical approaches to facilitate optimal decision-making, including automation and AI/modeling integration
Promote scientific excellence through internal and external presentations and publications

About you

PhD in chemistry, pharmaceutical science, material science, or related fields with minimum 3 years of postdoctoral experience in a pharma or biopharma environment
In-depth experience with solid-state characterization instruments: XRPD, DSC, TGA
Expertise in polymorphism/salt selection and understanding of powder and particle properties
In-depth understanding of pharmaceutical solid-state properties

Preferred Qualifications

Experience with SEM, Raman, IR, or laser granulometry
Demonstrated expertise in crystallography and computational prediction
Experience in crystal structure resolution by sc-XRD
Experience in crystallization of synthetic molecules (e.g., crystallization process, single-crystal growth, etc.)

Soft Skills

Good oral and written communication skills and ability to communicate effectively in individual and group settings
Ability to collaborate effectively in a multi-disciplinary team environment
Record of adhering to and promoting lab safety practices
Open-minded, agile, and capable of innovating in a complex environment

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