Scientist, Target Discovery & Validation

About the role

The Target Discovery and Validation group at Alnylam is seeking a motivated and knowledgeable Scientist in the early target space. This is an exciting time at Alnylam, with our liver platform well validated and rapidly expanding to more and more tissues and indications.

Responsibilities

• Work closely with Alnylam’s human genetics, multi-omics, platform and clinical teams to identify promising novel targets.
• Contribute to Alnylam’s target identification efforts that are based on human genetics, literature, academic collaborations, genomic approaches, etc.
• Design and execute proof of concept experiments in animal and in vitro disease models.
• Design studies, coordinate activities, and lead from the bench.
• Select drug candidates for further development.
• Develop assays to monitor target engagement/pharmacodynamic responses.
• Manage relationships with contract research organizations (CROs) and/or academic collaborators, including development of research plans and data analysis.
• Mentor junior scientists.
• Collaborate and communicate results with key stakeholders throughout the organization.

Qualifications

• PhD in biology or biomedical sciences-related field.
• Post doc or 1-2 years of experience strongly preferred.
• Strong publication record.
• Existing focus on disease biology and prior experience with mammalian disease models is also preferred.
• Experience in using human genetics to support biological mechanisms is a plus.
• Solid organizational skills and ability to multitask are a must.

Benefits

This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.