Senior Scientist - Experimental Protein Design for Target Discovery

Key Responsibilities

• Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for bindertarget evaluation.
• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.
• Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.
• Analyze and interpret experimental data to guide iterative design-build-test cycles.

Basic Qualifications

• Doctorate degree PhD
• OR PharmD
• OR MD [and relevant post-doc experience on Protein Engineering]
• OR Masters degree and 3 years of Protein Engineering experience
• OR Bachelors degree and 5 years of Protein Engineering experience

Preferred Qualifications

• Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience.
• Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, minibinders, or other designed scaffolds in a high-throughput or library-based manner. Experience with different expression hosts (cell-free expression, E. coli, and mammalian) is a plus.
• Experience in binder hit validation using flow cytometry and SPR, and in developing cellular-based assays for functional characterization.
• Experience working with designed binders or proteinprotein interaction engineering, with working knowledge of protein structurefunction relationships.
• Experience and interest in collaborating with computational protein design teams and translating in silico designs into experimentally testable reagents.
• Experience with automation platforms and high-throughput experimentation is a plus.
• Experience supporting phenotypic screening, receptor biology, or early target characterization is a plus.
• Strong organizational and communication skills, with the ability to work effectively in cross-functional discovery teams.