Senior Scientist - Experimental Protein Design for Target Discovery

About the role

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Responsibilities

• Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder–target evaluation.
• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.
• Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.
• Analyze and interpret experimental data to guide iterative design-build-test cycles.

Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc experience on Protein Engineering] OR Master’s degree and 3 years of Protein Engineering experience OR Bachelor’s degree and 5 years of Protein Engineering experience.
• Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience.
• Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, minibinders, or other designed scaffolds in a high-throughput or library-based manner.
• Experience with different expression hosts (cell-free expression, E. coli, and mammalian) is a plus.
• Experience in binder hit validation using flow cytometry and SPR, and in developing cellular-based assays for functional characterization.
• Experience working with designed binders or protein–protein interaction engineering, with working knowledge of protein structure–function relationships.
• Experience and interest in collaborating with computational protein design teams and translating in silico designs into experimentally testable reagents.
• Experience with automation platforms and high-throughput experimentation is a plus.
• Experience supporting phenotypic screening, receptor biology, or early target characterization is a plus.
• Strong organizational and communication skills, with the ability to work effectively in cross-functional discovery teams.