Scientist/Sr. Scientist-Preclinical Antibody Drug Development
Biocytogen · Waltham, MA · 1 wk ago
AnalystFull-time
Key Responsibilities
- Select and evaluate therapeutic targets with a strong understanding of MOA, druggability, and delivery options.
- Design experimental strategies to advance candidates from Biocytogen’s RenBiologics Antibody Binder/Lead Library toward therapeutic development.
- Drive projects by assembling resources, managing timelines, and ensuring alignment with program objectives.
- Engineer antibodies to improve affinity, specificity, stability, and manufacturability.
- Optimize antibodies through advanced molecular designs, such as Fc engineering or bispecific formats.
- Evaluate lead antibodies for binding, function, and developability, ensuring readiness for preclinical development.
- Work with discovery, manufacturing, and BD licensing teams to advance and out-license antibody assets.
- Maintain clear documentation and present findings to internal and external stakeholders.
Requirements
- PhD in Biochemistry, Molecular Biology, Immunology, or a related field with 2+ years of relevant experience, or MS with 5+ years of experience in antibody engineering and project management.
- Strong expertise in target biology research, including understanding MOA, druggability, and formulation requirements.
- Proven experience in antibody engineering and optimization, including affinity maturation and stability improvement.
- Demonstrated ability to independently drive projects, assemble resources, and meet critical milestones.
- Excellent collaboration and communication skills for working with cross-functional teams and presenting findings effectively.
Benefits
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Health Reimbursement Accounts
- Life and AD&D Insurance
- Short & Long Term Disability Insurance
- 401K with Company Match
- Paid Time Off
- Paid Sick Days & Holidays