Scientist (Multi-specific Antibody Development)

Responsibilities

• Contribute to the design of multi-specific antibodies and oversee their production/purification.
• Design, execute, and lead in vitro functional studies supporting the validation of target combinations, lead selection, and preclinical development of multi-specific TCEs.
• Develop, optimize, and perform functional assays to inform potency, selectivity, and safety (e.g., cytotoxicity, cytokine release, reporter assays).
• Generate and interpret complex datasets with a strong emphasis on scientific rigor, reproducibility, and data quality.
• Build decision-focused data packages and communicate clear scientific conclusions and recommendations to project teams and management.
• Familiarity with diverse antibody platforms and strategies for the design and production of multi-specific antibodies.
• Optimize and characterize binding properties of multi-specific antibodies (ELISA, flow cytometry, cell bridging assays).
• Develop and execute multiparameter flow cytometry to assess T-cell activation.
• Design and perform real-time cytotoxicity assays (e.g., IncuCyte, eSight) and other functional readouts relevant to T-cell engager activity (e.g., reporter assays).
• Design and generate engineered cell systems, including overexpression and CRISPR-based knockout models.
• Isolation and maintenance of primary immune cell populations (e.g., PBMCs, T-cells).
• Collaborate closely across teams to evaluate and optimize multi-specific TCEs.
• Coordinate with CROs to deliver high quality, timely data.
• Proactively identify project risks, propose mitigation strategies, and communicate progress and challenges clearly to stakeholders.
• Monitor the scientific literature and competitive landscape relevant to multi-specific TCEs and emerging immune redirecting modalities.
• Propose innovative experimental approaches to accelerate early-stage discovery.
• Monitor the scientific literature and competitive landscape relevant to OGAP-selected targets.
• Foster a culture of scientific rigor, learning, transparency, accountability, and inclusion.
• Contribute scientific expertise and innovative thinking to project teams.
• Adhere to OBT’s Quality Management System (QMS), including SOPs, documentation standards, electronic lab notebooks, and required training.
• Support audit readiness and contribute to continuous improvement of laboratory systems and workflows.

Qualifications

• Experience supporting the discovery, characterization, and optimization of T-cell engagers, bispecific antibodies or other immune redirecting biologics.
• Experience with stable cell line generation (Lentiviral transduction, CRISPR KO).
• Expertise with antibody binding assays (ELISA, flow cytometry).
• Immune cell co-culture cytotoxicity assays with live readouts (Incucyte, eSight).
• Multiparameter flow cytometry and panel design.
• T-cell activation assays (Reporter assays, immune-profiling and cytokine secretion).
• Demonstrated ability to design, analyse, and interpret complex datasets and translate results into clear scientific conclusions.
• Strong written and verbal communication skills, with the ability to present data to multidisciplinary audiences.
• A humble, team-oriented mindset with the ability to form and voice clear, independent viewpoints.