Principal Scientist – Antibody Discovery/Protein Design
EvolveImmune Therapeutics · Branford, CT · 2 mo ago
Art & CreativeFull-time
About the role
A Principal Scientist to join our Biotherapeutics group focused on designing and advancing first-in-class immune-engaging biologics.
Responsibilities
- Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery
- Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization
- Optimize developability in lead optimization through computational and biophysical insights
- Expand company computational protein design tools and capabilities
- Collaborate across functional teams to support candidate selection and preclinical development
- Present findings in a clear, compelling way to multidisciplinary teams
- Mentor junior scientists and help shape our growing discovery efforts
Requirements
- PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience
- Foundation in protein design and molecular modeling using AI/ML
- Yeast or alternative antibody display technologies experience from design through screening
- Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization
- Strong communication, data interpretation, and cross-functional collaboration skills
Qualifications
- Expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologies
- Interest in advancing drug candidates toward first-in-patient evaluation
Skills
- Strong communication, data interpretation, and cross-functional collaboration skills
Benefits
- Competitive salary
- Benefits
- Equity
- Paid time off
Pay
- Competitive salary
Schedule
- Full-time, onsite position based in Branford, CT
Additional Info
- EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
- We are an equal opportunity employer and value diverse perspectives in all aspects of our work
- Learn more about our science and our team at www.evolveimmune.com