Principal Scientist (Antibody Engineering)

About the role

GigaGen, a subsidiary of Grifols, discovers and develops next-generation recombinant antibody therapeutics. Our core technology utilizes a microfluidic droplet system to capture and immortalize diverse immune repertoires, which can then be mined for exceptional monoclonals or enriched and used as high-potency polyclonal therapeutics. Our pipeline includes several recombinant polyclonal products for infectious diseases and a monoclonal antibody with a unique mechanism for oncology, with several projects in the clinic.

Responsibilities

• Independently design and manage experiments for testing next-generation antibody therapeutics, including construct design, expression and purification strategies, and implementation of novel analytical assays.
• Provide technical leadership for complex projects which may include elements of protein engineering, synthetic biology, high-throughput sequencing, and in vitro assays.
• Contribute ideas for new assays and technologies to enable the next-generation of GigaGen products and work with management to obtain support and resources to be successful.
• Stay abreast of cutting-edge tools and new technologies related to GigaGen’s antibody discovery platform and coordinate for testing and implementation.
• Contribute to brainstorming sessions and troubleshooting efforts within the team.
• Propose and manage goals, timelines, and personnel for multiple projects, and drive internal and external communications within and across teams to ensure goals are met on time.
• Synthesize and interpret complex data for internal and external presentations.
• Mentor junior lab staff, with opportunities for management of one or more staff.
• Initiate and manage projects with external vendors.

Requirements

• PhD in chemical/biological engineering, biochemistry, molecular biology, or similar preferred
• 8+ years industry and/or Post-PhD experience OR MS with 12+ years of industry experience OR Bachelors with 15+ years of industry experience
• Strong background in a relevant scientific field, as evidenced by publications and conference presentations
• Broad technical background covering additional areas of interest
• Experience managing and mentoring direct reports
• Experience managing CROs and external collaborations
• Technical writing skills and experience authoring SOPs, manuscripts, or other documents
• Able to work in a fast-paced team environment, meet deadlines, and prioritize work across multiple projects
• Strong written and verbal communication skills, and efficient in communicating in interdisciplinary and cross-functional teams
• Advanced ability to creatively apply scientific principles in problem solving in potentially novel areas.

Qualifications

• PhD in chemical/biological engineering, biochemistry, molecular biology, or similar preferred
• 8+ years industry and/or Post-PhD experience OR MS with 12+ years of industry experience OR Bachelors with 15+ years of industry experience
• Strong background in a relevant scientific field, as evidenced by publications and conference presentations
• Broad technical background covering additional areas of interest
• Experience managing and mentoring direct reports
• Experience managing CROs and external collaborations
• Technical writing skills and experience authoring SOPs, manuscripts, or other documents
• Able to work in a fast-paced team environment, meet deadlines, and prioritize work across multiple projects
• Strong written and verbal communication skills, and efficient in communicating in interdisciplinary and cross-functional teams
• Advanced ability to creatively apply scientific principles in problem solving in potentially novel areas.

Skills

• Significant experience in antibody and antigen engineering
• Experience in protein expression and purification
• Advanced cloning techniques
• Experience in mammalian synthetic biology, single-cell assays, bioinformatics, automation, droplet microfluidics, bacterial or yeast biology, or related areas

Benefits

Final compensation packages will ultimately depend on education, experience, skillset, knowledge, where the role is performed, internal equity and market data. We are committed to offering our employees opportunities for professional growth and career progression. Grifols is a global healthcare organization with employees in 30 countries focused on patient health and providing impactful results. Since our humble beginnings in 1909, Grifols has been a family company that prides itself on its family-like culture. Our company has more than tripled over the last 10 years, and you can grow with us!

Pay

The estimated pay scale for Principal Scientist role based in California, is $165,000.00 to $205,000.00 per year. Additionally, the position is eligible to participate in the company bonus pool. We offer a wide variety of benefits including, but not limited to: Medical, Dental, Vision, life insurance, PTO, paid holidays and up to 5% 401(K) match and tuition reimbursement.