Scientist/Sr Scientist- Immunology

About the role

The successful candidate will oversee the day-to-day operations, instrument maintenance, method development, and user training for cutting-edge MALDI mass spectrometry imaging (MSI) platform. This role is uniquely positioned at the intersection of immunology, metabolism, and spatial biology.

Responsibilities

• Develop, execute, and oversee specialized methods for mapping metabolites, lipids, proteins/peptides, and other small molecules in diverse immune and tumor microenvironments.
• Oversee daily operations, calibration, optimization, and routine maintenance of core MALDI/DESI imaging mass spectrometers.
• Analyze complex spatial metabolomics and related datasets, integrate them with multi-omics datasets (e.g., spatial transcriptomics and multiplexed antibody imaging) as needed, and interpret tissue features and biological insights.
• Collaborate with other cores and shared resources to integrate spatial metabolomics datasets with high-dimensional data acquired from additional platforms such as spatial transcriptomics and proteomics (multi-omics) platforms.
• Collaborate with principal investigators and/or lab personnel to design well-powered spatial immunology experiments and provide support for grant and paper preparations.

Requirements

• Extensive hands-on experience in operating and troubleshooting MSI instrumentation.
• Familiarity with MSI data analysis, computational methodologies, and integrative analysis of MSI and other high-dimensional datasets (e.g., spatial transcriptomics and multiplexed antibody imaging).
• A strong understanding of immune or cancer metabolism, particularly in tissue-specific contexts.

Qualifications

• Minimum Education: Bachelor's degree in relevant scientific area is required.
• Senior Scientist: Ten (10) years relevant work experience is required.
• Scientist: Eight (8) years of relevant work experience is required with a Master's degree, or Six (6) years with a PhD, or Three (3) years with a PhD.

Skills

• Experience with MALDI mass spectrometry imaging (MSI) instrumentation.
• Knowledge of computational methodologies and integrative analysis of spatial metabolomics and related datasets.
• Understanding of immune or cancer metabolism, particularly in tissue-specific contexts.

Benefits

Explore our exceptional benefits!

Pay

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Scientist/Sr Scientist- Immunology.

Schedule

N/A