Scientist, Immunology

Core Responsibilities

• Review the literature to gain a comprehensive understanding of internal therapeutic targets of interest
• Design experiments to confirm the mechanism of action of small molecule hits from our binding and virtual screens in cells
• Independently develop, optimize, and run cell-based assays to profile on- and off-target activity of hits and hit series
• Adapt assays for medium to high-throughput screening and IC50 generation to support structure-activity-relationship understanding
• Manage CROs for reagent development and/or in vitro testing as needed
• Analyze and interpret experimental data and communicate results in project team meetings
• Interface with a multidisciplinary team (including chemists and computational scientists) as the immunology representative to drive decision-making
• Support organization of lab and equipment as needed

Experience and Qualifications

• PhD in the field of immunology, molecular or cell biology, or related field with 3+ years of small molecule drug discovery experience
• Or MSc with 10+ years of small molecule drug discovery industry experience
• Strong background in immunology and immune signaling pathways
• Extensive hands-on experience with cell culture and cell-based assays, including reporter assays, gene and protein expression (eg: Flow cytometry, qPCR, RNAseq, Luminex, MSD, ELISA, Western) and intracellular techniques
• Experience establishing robust assays for small molecule dose responses and IC50 generation
• Excellent organizational, interpersonal and communication skills, and can thrive in a highly collaborative research environment
• Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data

Compensation Details

$120,000 – $175,000 annually, depending on experience.