Scientist, Solid Tumor CAR-T

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases.

About the role

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies. The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Responsibilities

• Design and execute in vitro CAR-T functional assays.
• Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets.
• Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
• Handling and engineering human and murine T cells as well as various cancer cells.
• Engineering and maintaining various cancer cell lines for model development.
• Analyze and interpret data, troubleshooting, maintain detailed experimental records.

Requirements

• A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
• Candidates completing their PhD within the past 3 years are strongly encouraged to apply.
• Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
• Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo).
• Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
• Experience with humanized mouse models for in vivo CAR-T evaluation.
• Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
• Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
• Experience with in vitro Organoid cancer model establishment and expansion.
• Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
• Contributions to innovation in cell therapy (publications, patents, or conference presentations).

Benefits

• Medical, dental, and vision insurance.
• 401(k) retirement plan with a company match that vests fully on day one.
• Eight (8) weeks of paid parental leave after just three (3) months of employment.
• Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
• Additional voluntary benefits including flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
• Voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs.

Pay

Base pay range: $110,706 - $145,303 USD. Performance-based bonus and/or equity is available to employees in eligible roles.

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.