Scientist/Senior Scientist, Assay Development - Neuroscience Biomarkers

Responsibilities

• Develop a portfolio of ultrasensitive immunoassays throughout the product lifecycle, from initial screening and optimization through feasibility, verification, and transfer.
• Plan, design, and execute hands-on assay-development studies, including antibody selection and pairing, reagent conjugation, buffer optimization, reference-material evaluation, matrix characterization, and analytical validation for research and future clinical applications.
• Provide scientific leadership and translate biomarker biology into assay-design strategies by optimizing for clinically relevant molecular forms, isoforms, post-translational modifications, cleavage fragments, epitopes, and sample types.
• Analyze data from clinical and preclinical samples and interpret findings in the context of disease biology, sample characteristics, and published literature.
• Collaborate closely with Platform, Product Development, Operations, and Business Development teams to transition assays from feasibility through verification and transfer.
• Prepare clear scientific presentations, technical reports, study summaries, abstracts, and publications.
• Contribute to a rigorous, accountable, and highly collaborative startup environment.

Requirements

• Ph.D. in Neuroscience, Neurobiology, Molecular Biology, Biochemistry, Biomedical Engineering, or a closely related field.
• Strong scientific expertise in fluid biomarkers and assay-development strategies for the diagnosis, stratification, or therapeutic monitoring of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, or related neurological disorders.
• Strong understanding of biomarker heterogeneity and the factors that influence measurement in human biofluids.
• Hands-on experience developing immunoassays or other quantitative protein-detection methods.
• Demonstrated ability to design experiments independently and troubleshoot technical challenges.
• Evidence of meaningful scientific contributions through peer-reviewed publications, patents, conference presentations, or translational research programs.
• Strong written and verbal communication skills.
• Experience working in a startup or fast-paced biotechnology environment.
• Can work 5 days/week on site in Woburn, MA.

Benefits

• Competitive compensation
• Meaningful stock ownership
• Comprehensive benefits
• A great work environment

Pay

Compensation Range: $115K