Scientist / Senior Scientist, Assay Development (Reagents)

About the role

Glyphic Biotechnologies is seeking a Scientist or Senior Scientist to build and sustain the reagent supply infrastructure that powers our single-molecule proteome sequencing platform. The ideal candidate brings deep hands-on expertise in biochemical reagent development with a quality-by-design mindset.

Responsibilities

• Reagent Development & Formulation
  • Lead assay reagent development activities, including formulation, characterization, and optimization, for components used in ProSE single-molecule expansion and library preparation workflows, including enzymes, oligos, beads, and solvents.
  • Characterize reagent performance using design-of-experiments (DOE) approaches, systematically varying formulation conditions, buffer composition, excipients, and process parameters to establish operating bounds and define product specifications.
  • Design and execute experiments to evaluate reagent performance in end-use assay configurations; develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes.
  • Develop, qualify, and transfer QC test methods for reagent characterization and lot release, including HPLC, fluorescence-based functional assays, and physical characterization methods; set product, process, and incoming material acceptance criteria in collaboration with Assay and cross-functional partners.
  • Qualify each reagent lot prior to use in multi-cycle or KOL runs; execute hands-on QC testing encompassing physical, chemical, and functional characterization; gate go/no-go decisions on input materials and maintain provenance records for high-stakes runs.
  • Maintain batch records and quality documentation in accordance with internal standards.
• QC Framework & Lot Qualification
  • Build and implement a QC and control framework for platform reagents, including acceptance criteria, lot release protocols, and QC assay development, to support reliable, consistent supply to the Assay team.
  • Establish and maintain SOPs for assay reagents and integrated workflows; systematically investigate lot-to-lot variability and failure modes; troubleshoot deviations and lead root cause analysis and corrective action.
  • Guard-band critical reagent components and workflow steps to establish the operating bounds of new protocols and define tolerance limits for expansion assay parameters.
  • Forecast and maintain end-to-end reagent inventory for SOP-level runs, ensuring the Assay team has qualified materials available on schedule for integration runs and platform demonstrations.
  • Partner with the Automation team to implement and qualify reagent-dependent assay steps on work cell or Hamilton-based platforms; qualify liquid-handling methods against reagent specifications.
  • Analyze experimental data using statistical methods; synthesize results to identify trends and trace them to upstream reagent, process, or formulation variables; communicate findings through technical reports and presentations, and maintain comprehensive documentation to ensure reproducibility and preserve institutional knowledge.
• SOPs, Inventory & Continuous Improvement
  • Establish and maintain SOPs for assay reagents and integrated workflows; systematically investigate lot-to-lot variability and failure modes; troubleshoot deviations and lead root cause analysis and corrective action.
  • Guard-band critical reagent components and workflow steps to establish the operating bounds of new protocols and define tolerance limits for expansion assay parameters.
  • Forecast and maintain end-to-end reagent inventory for SOP-level runs, ensuring the Assay team has qualified materials available on schedule for integration runs and platform demonstrations.
  • Partner with the Automation team to implement and qualify reagent-dependent assay steps on work cell or Hamilton-based platforms; qualify liquid-handling methods against reagent specifications.
  • Analyze experimental data using statistical methods; synthesize results to identify trends and trace them to upstream reagent, process, or formulation variables; communicate findings through technical reports and presentations, and maintain comprehensive documentation to ensure reproducibility and preserve institutional knowledge.

Requirements

• Required:
  • PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist)
  • PhD / MS / BS with 2+ / 4+ / 6+ years of relevant experience (Scientist II)
  • Proven bench expertise in reagent development or analytical science, with hands-on experience across biochemical characterization techniques with the ability to establish operating bounds and guard bands for critical reagent and process parameters.
  • Deep understanding of reagent formulation principles and their influence on stability and functional performance; with practical experience across the full reagent development cycle including formulation, stability studies, and QC method development.
  • Experience working with chemically reactive or environmentally sensitive compounds, including materials susceptible to degradation by oxygen, humidity, or light, with appropriate handling, storage, and stability assessment practices.
  • Strong experimental design skills, with the ability to plan and execute DOE-informed studies and interpret results against specifications.
  • Experience developing reagents for multistep, integrated assay workflows involving multiple handoff points or checkpoints, including multi-omics or multi-component platforms.
  • Experience establishing and maintaining robust SOPs for end-to-end integrated workflows, with consistent capture of key experimental variables, reagents, and process conditions — enabling cross-functional traceability and correlation with downstream data and performance.
  • Excellent problem-solving skills and meticulous attention to detail.
  • Strong written and verbal communication skills, with the ability to work effectively with colleagues across diverse scientific and technical backgrounds.
  • Comfortable navigating a fast-paced, resource-constrained environment with shifting priorities.
• Nice to have:
  • Background in proteomics reagents, protein modification chemistry, peptide-oligonucleotide conjugates, or single-molecule assay components.
  • Experience with automation platforms for liquid handling (e.g., Hamilton, ThermoFisher, Agilent) and protocol validation on automated workcells.

What you can expect from this role

Work environment: Collaborative culture where your ideas and expertise are valued
Professional growth: Learn from a diverse team of world-class scientists and engineers
Contribute to first-of-their kind technologies, high-impact publications, and patents
Compensation: Estimated Base Salary $111,725 - $161,900
This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location.
Benefits and Perks: Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.