Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics

Responsibilities

• Design and develop ultrasensitive protein-detection assays from concept through feasibility, optimization, analytical characterization, verification, and transfer.
• Develop and optimize antibody and protein-reagents to maximize analytical and clinical performance, including antibody selection, protein structural properties, epitope-pair assessment, conjugation chemistry, reagent purification, and stability evaluation.
• Troubleshoot assay-performance issues, including low signal, nonspecific background, limited sensitivity, poor reproducibility, matrix effects, instability, and lot-to-lot variability, using a mechanistic understanding of binding kinetics, affinity, avidity, thermodynamics, steric effects, and molecular interactions.
• Design efficient experiments and use structured approaches, including design of experiments where appropriate, to identify root causes and optimize performance.
• Collaborate closely with Platform, Product Development, Operations, and Business Development teams to transition assays from feasibility through verification and transfer.
• Prepare clear scientific presentations, technical reports, study summaries, abstracts, and publications.

Requirements

• Ph.D. in Chemistry, Analytical Chemistry, Biophysics, Chemical Engineering, Biochemistry, Bioengineering, Molecular Engineering, or a closely related field.
• Strong fundamental understanding of molecular interactions involving nucleic acids, proteins, or both.
• Experience with protein–protein and antigen–antibody interactions, including affinity, avidity, kinetics, and thermodynamics.
• Demonstrated hands-on experience creating and designing immunoassays, protein-detection methods, molecular-diagnostics assays, or an innovative life-science analytical platform.
• Strong experimental-design and troubleshooting skills, with the ability to develop mechanistic hypotheses and test them efficiently.
• Demonstrated ability to work independently, analyze complex data, and make sound technical decisions.
• Evidence of meaningful scientific contributions through peer-reviewed publications, patents, conference presentations, or platform-development programs.
• Strong written and verbal communication skills.
• Ability to work onsite five days per week in Woburn, Massachusetts.

Qualifications

• Candidates must be based in the Greater Boston area or able to relocate before the start date.
• Can work 5 days/week on site in Woburn, MA.

Skills

• Hands-on research ownership.
• Understanding of molecular interactions.
• Experience with protein-detection methods.
• Experimental-design and troubleshooting skills.
• Independent problem-solving abilities.

Benefits

• Competitive compensation.
• Meaningful stock ownership.
• Comprehensive benefits.
• Great work environment.

Pay

Compensation Range: $115K

Schedule

This role is based onsite in our lab in Woburn, MA 5 days/week.