Scientist, Oligonucleotide Synthesis

About the role

The successful candidate will help to establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development.

Responsibilities

• Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries.
• Perform hands-on work, maintain high-throughput automation workflows in support of routine and next generation chemistry and oligo method development.
• Maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results.
• Work with the oligo analytical and delivery chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Collaborate with various teams to achieve synthetic project goals.

Requirements

• MS with 2+ or BS with 4+ years of experience in chemistry or chemical biology or related field.
• Direct experience with laboratory automation platforms, such as the Lynx from Dynamic Devices, the Fluent from Tecan or other similar platforms.
• Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high-throughput synthesizers, LC/HRMS, UPHLC, LC/MS analytics.
• Proficiency in oligonucleotide synthesis (SPOS), and biological understanding of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors).

Qualifications

• Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions.
• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.
• Experience with oligonucleotide conjugation chemistries is desirable but not required.
• Sense of urgency, flexibility, independence and accountability.
• Able to communicate both verbally and in writing with all levels both inside and outside of organization.
• Maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Committed team player prepared to work in and embrace a team-based culture.

Benefits

We offer a range of benefits including health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Pay

The US salary ranges for this position are $96,525 to $160,875 annually. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role.

Schedule

This is an on-site role based at our Cambridge, MA laboratory location. You will be expected to work in the lab regularly to run and support experimental workflows. Hybrid or remote arrangements are not available for this position.