Scientist, mRNA/cDNA/Cell-Free Display
Manifold Bio · Boston, MA · 3 wk ago
Research$118k–$138k/yrFull-time
Responsibilities
- Design, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats
- Work with automation team to scale and automate the platform to enable routine, high-throughput screening against large panels of therapeutic targets
- Collaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines
- Work with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows
- Stay current on advances in cell-free display, laboratory automation, and computational protein design
Required Qualifications
- PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or a related field
- Hands-on experience with cell-free selection systems (cDNA display, mRNA display, ribosome display, or similar)
- Strong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows
- Experience with or strong interest in laboratory automation
Preferred Qualifications
- Track record of successfully automating complex laboratory workflows
- Background in therapeutic antibody discovery or protein engineering
- Experience with computational protein design
- Familiarity with how high-throughput screening data feeds into ML and computational pipelines
- Experience with complex or non-traditional binder formats and biochemical intuition to adapt selection workflows accordingly
Pay
Base Salary Range: $118,000-138,000
Schedule
This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.
Benefits
- Annual performance-based target bonus
- Stock options
- Comprehensive medical, dental, and vision coverage
- 401(k) plan
- Flexible paid time off and holidays
- Perks including on-site gym, onsite lunch, and commuter support
Equal Opportunity Employer
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.