Scientist - III (Senior)

Responsibilities

• Execute and troubleshoot molecular interaction studies supporting antibody discovery, hit identification, lead optimization, and candidate selection.
• Generate and analyze binding affinity, kinetics, avidity, epitope binning, competition, and developability data for antibodies, bispecifics, and other biologics.
• Operate and optimize molecular interaction platforms including SPR, Carterra, Biacore, BLI, KinExA, and related technologies.
• Perform protein characterization and quantitative analysis of protein-protein interactions.
• Design assay plans, establish appropriate controls, and interpret complex interaction data to support discovery decisions.
• Optimize assay workflows for robustness, throughput, data quality, and turnaround time.
• Troubleshoot assay and instrument issues and support protocol, analysis template, and workflow development.
• Document experimental methods, results, data quality assessments, and conclusions in laboratory systems and technical reports.
• Support data analysis, visualization, and workflow improvements for molecular interaction studies.

Requirements

Education: Master's degree in Biophysics, Biochemistry, Chemistry, Molecular Biology, Protein Sciences, Biomedical Engineering, or related field with 5+ years of hands-on experience. PhD in a related field preferred with 3+ years of hands-on experience.

• Biomolecular interactions
• Protein characterization
• Protein-protein interaction analysis
• Surface Plasmon Resonance (SPR)
• Carterra
• Biacore
• Bio-Layer Interferometry (BLI)
• KinExA
• Binding affinity and kinetic analysis
• Antibody/protein interaction assays
• Molecular interaction data analysis
• Assay troubleshooting
• Quantitative data interpretation

Preferred Skills

• Therapeutic antibody discovery
• Bispecific antibody characterization
• Epitope binning
• Competition assays
• Cell binding characterization
• Receptor pharmacology
• Developability assessment
• Antibody engineering
• Fc biology
• Protein structure-function analysis
• Flow cytometry
• High-throughput screening
• Laboratory automation
• Python
• R
• Spotfire

Pay

$76.97/hr

Schedule

6 Months