Scientist II, Complex In Vitro Model

AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology, and neuroscience—and products and services in our Allergan Aesthetics portfolio.

About the role

The Complex In Vitro Model group is seeking a scientist to support the design, execution, and interpretation of in vitro studies on the characterization of drug candidate molecules and the validation of drug targets.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines, and complex in vitro systems such as organoids or organ-on-chip models.
• Analyze, interpret, and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintain accurate and current records of research.

Requirements

• BS or MS in Biological Science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high-content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
• Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Pay

The compensation range described is the range of possible base pay the company believes in good faith it will pay for this role at the time of posting, based on the job grade. Individual compensation paid within this range will depend on many factors including geographic location, and may vary.

Benefits

• Comprehensive package of benefits including paid time off (vacation, holidays, sick).
• Medical, dental, and vision insurance.
• 401(k) to eligible employees.
• Eligibility to participate in short-term incentive programs.