Scientist, II

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube. Job Description AbbViesGastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated andexperienced invivo and in vitropharmacologistto play an integral role inadvancing therapeuticsto treat inflammatory GI disorders.This position offers an exciting opportunity tounderstand thepharmacodynamic effectsof experimental medicineswith GI relevant in vitro and in vivo assays. The ideal candidate would work within the highly matrixed and collaborativeDiscovery Immunologyteam toguidetest articlescreening and assay development as well asbuild biology packages forearly stageprograms.Experimental focus will be ondeveloping andleveragingin vivo and in vitro systems tohelpunderstand the impact of test articlesinmucosal immunity.The candidate is expected to design, execute,interpretand present innovative research to advance programstowards the clinic.We are seeking a hands-on experimentalist who isproficientwithin vivo and in vitrocell biology research andhasdemonstratedscientificleadership withinternal and externalstake holders/experts.The expectation is that the candidate would dedicatethe majority oftheir time toward wet lab experimentation, dataanalysisand presentation.In addition, we are seeking a candidatewith excellent written and oral communication skills.The candidate will have the opportunity to present their results at team and internal/external science meetings.Priortechnicalexperience inIBDmouse models, humanized mice,biologicsmolecule screening, and handling of human tissuearerequired. Major Responsibilities Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisorExecute ondiscovery screening funnels fornovel test articlesDesign, execute and analyze in vivopharmacologystudies in colitis or other GI mouse modelsPrepareand execute experiments withhuman blood or intestinal tissueFormulate conclusions and design follow-on experiments based on multidisciplinary dataPrimary author of regulatory documents.Understand and adhere to corporate standardsregardingcode of conduct, safety,appropriate handlingof materials, controlled drug and radioactive compounds, and animal care Qualifications Bachelors Degree or equivalent education and typically,7years ofworkexperience,Masters Degreeor equivalent education and typically5years of work experienceExperiencewithin vitro and in vivocell killingendpoints preferredHighly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulationis preferredExperience with ex vivo intestinal tissue assaysPossess thorough theoretical and practical understanding ofownscientific discipline, especially within gastrointestinal physiology and inflammation.Highly proficientand efficientwithin vivo techniques such as mouse restraint, PO, ROand IP dosing routes, and rodent necropsy.Experience with some colitis modelsor humanize mouse modelsisrequired.Technical capabilities including RT-qPCR,Westernblot,multi-parameterflowcytometryDemonstrated ability to learn,understandand master new experimental techniques.Demonstrated scientific writing skills and strong verbal communication skillsthrough publication and conference presentations. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html