Scientist, II

About the Role

AbbVie's Gastrointestinal (GI)/Immunology Discovery Research group is seeking a highly motivated and experienced in vivo and in vitro pharmacologist to play an integral role in advancing therapeutics to treat inflammatory GI disorders. This position offers an exciting opportunity to understand the pharmacodynamic effects of experimental medicines with GI-relevant in vitro and in vivo assays.

The ideal candidate will work within the highly matrixed and collaborative Discovery Immunology team to guide test article screening and assay development as well as build biology packages for early-stage programs. Experimental focus will be on developing and leveraging in vivo and in vitro systems to help understand the impact of test articles in mucosal immunity. The candidate is expected to design, execute, interpret, and present innovative research to advance programs towards the clinic.

We are seeking a hands-on experimentalist proficient with in vivo and in vitro cell biology research who has demonstrated scientific leadership with internal and external stakeholders/experts. The expectation is that the candidate would dedicate the majority of their time toward wet lab experimentation, data analysis, and presentation. In addition, we are seeking a candidate with excellent written and oral communication skills. The candidate will have the opportunity to present their results at team and internal/external science meetings.

Major Responsibilities

• Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor
• Execute on discovery screening funnels for novel test articles
• Design, execute, and analyze in vivo pharmacology studies in colitis or other GI mouse models
• Prepare and execute experiments with human blood or intestinal tissue
• Formulate conclusions and design follow-on experiments based on multidisciplinary data
• Primary author of regulatory documents
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and animal care

Qualifications

• Bachelor's Degree or equivalent education with typically 7 years of work experience, OR Master's Degree or equivalent education with typically 5 years of work experience
• Prior technical experience in IBD mouse models, humanized mice, biologics molecule screening, and handling of human tissue is required
• Highly proficient and efficient with in vivo techniques such as mouse restraint, PO, RO, and IP dosing routes, and rodent necropsy
• Technical capabilities including RT-qPCR, Western blot, multi-parameter flow cytometry
• Possess thorough theoretical and practical understanding of own scientific discipline, especially within gastrointestinal physiology and inflammation
• Demonstrated ability to learn, understand, and master new experimental techniques
• Demonstrated scientific writing skills and strong verbal communication skills through publication and conference presentations

Preferred Skills

• Experience with in vitro and in vivo cell killing endpoints
• Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulation
• Experience with ex vivo intestinal tissue assays
• Experience with colitis models or humanized mouse models

Pay & Benefits

The compensation range is based on the job grade for this position, with individual compensation depending on factors including geographic location. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs.