Scientist I (Scientific)

Job Summary

We are seeking a skilled Scientist I (Scientific) for a premier 1-year, 100% onsite role in Waltham, MA. Joining a Top-Tier Global Pharma Leader within their Genomic Medicine Unit, you will focus on the design, optimization, and scale-up of viral and non-viral gene therapy purification processes. This laboratory-based role (70-80% lab time) offers an excellent environment for driving bioprocess innovation with advanced downstream technologies.

Responsibilities

• Lead and conduct viral/non-viral vector purification process development and process analytics.
• Optimize purification processes utilizing downstream technologies, including column chromatography and filtration unit operations.
• Develop, conduct, and maintain analytical assays (ELISA, DLS, Octet, qPCR, HPLC, CE-SDS) for in-process sample testing.
• Perform data analysis, troubleshoot experiments, and communicate findings across internal and external teams.
• Support technology transfer activities to CDMOs and lead manufacturing scale-up initiatives.
• Mentor junior staff and contribute to technical reports and regulatory documentation.

Qualifications

• Required: PhD in Biotechnology, Biochemistry, Chemical Engineering (or related discipline) with 0-3 years of experience; OR a Master's degree with 4+ years of experience; OR a Bachelor's degree with 6+ years of professional biotech industry experience.
• Hands-on protein purification chromatography and filtration experience (depth filtration, TFF).
• Proven experience with modern analytical techniques (spectrophotometry, ELISA, DLS, Octet, qPCR, or HPLC).
• Strong understanding of tech transfers, gap analyses, and Quality by Design (QbD)/DOE principles.
• Critical thinking and excellent professional communication skills.

Preferred Experience

• In AAV or non-viral purification development.
• Late-stage purification experience (design space mapping and process robustness studies).

Skills

• Chromatography
• Protein Purification
• High Pressure Liquid Chromatography (HPLC)
• Good Laboratory Practices (GLP)
• Dynamic Light Scattering (DLS)
• Gel Electrophoresis (SDS-PAGE)
• Enzyme-Linked Immunosorbent Assay (ELISA)

Benefits

• Medical
• Prescription
• Dental
• Vision
• AD&D
• Life Insurance
• Short-term Disability
• 401K Plan