Scientist I, In Vivo Pharmacology

About the Role

Our expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives.

The successful candidate will have expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice. Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential. Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.

Responsibilities

• Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic).
• Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.
• Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq.
• Identify, validate and utilize humanized mouse models to support AbbVie pipeline assets.
• Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.
• Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques.
• Appetite for developing novel in vivo approaches and models to address complex biological questions.

Qualifications

• BS with 5+ years of experience or MS with 2+ years with a degree in physiology, pharmacology, molecular biology or any related field of biology is required.
• Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation (subcutaneous, disseminated etc.), tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection.
• Familiarity with huPBMC and CD34 humanized mice is highly desired.
• Experience with mouse models of cancer, including CDX and/or PDX xenograft models is preferred.
• Familiarity with data analysis, presentation, data management, and statistical software (e.g. Microsoft Office, Study Director, GraphPad Prism) is a plus.
• Grounding in ADC or TCE therapeutics is desired.

Skills

• Builds strong relationships with peers and cross-functionally with partners outside the team to enable higher performance.
• Learns quickly and changes course when indicated.
• Raises the bar and is never satisfied with the status quo.
• Embraces others' ideas, nurtures innovation and brings it to reality.

Benefits

• Comprehensive package of benefits including paid time off (vacation, holidays, sick).
• Medical, dental, and vision insurance.
• 401(k) to eligible employees.
• Eligibility to participate in short-term incentive programs.

Pay

The compensation range described is the range of possible base pay that AbbVie believes in good faith it will pay for this role at the time of posting, based on the job grade. Individual compensation paid within this range will depend on many factors including geographic location, and may ultimately differ from the posted range. This range may be modified in the future.