Scientist I, Histology

Responsibilities

• Translate study requirements into practical histology work plans (sampling schemes, section levels, stain menus, controls, timelines)
• Present interim results to program stakeholders
• Cook up specimen receipt, accessioning, labeling/barcoding, and chain-of-custody
• Maintain complete, accurate, audit-ready records in LIMS/ELN or designated systems
• Perform routine automated tissue processing and paraffin embedding
• Cryosection a range of animal tissues at 5–7 µm; complete re-cuts and serial levels as needed with minimal artifacts
• Execute H&E, special stains, and IHC/IF on manual and automated platforms, including antigen retrieval, antibody titration, protocol design, and troubleshooting
• Contribute to method validation (e.g., RNAscope/miRNAscope, multiplex IHC/IF)
• Perform microscopic QC, identify representative regions, and use imaging/slide scanning as available to support digital pathology
• Compile clear data summaries and presentations for study leads
• Adhere to SOPs and applicable quality expectations
• Follow biosafety and chemical-safety procedures
• Participate in deviations/CAPA as appropriate
• Contribute to team-based improvements (e.g., 5S/Lean)
• Operate and perform routine maintenance/calibration checks for microtomes, cryostats, stainers, printers, microscopes
• Track reagents/antibodies and coordinate ordering and lot qualification

Requirements

• BS or MS degree in Cell Biology, Molecular Biology, Biochemistry, or related discipline
• BS with a minimum of seven (7) years relevant histology laboratory experience or a MS with 3+ years of academic/industry laboratory experience
• Proficiency with microtomes, cryostats, cassette/slide printers, automated slide stainers, and microscopes; practical knowledge of tissue composition
• Extensive experience in IHC/IF staining, protocol development, validation, and troubleshooting (including antibody titration and antigen retrieval)
• Strong project- and time-management skills with the ability to manage multiple studies and deadlines; effective written and verbal communication
• Advanced computer skills (e.g., Excel and imaging software)
• Ability to process valuable/delicate samples and to prepare tissue for pathologist interpretation
• Preferred: Degree from an accredited Histotechnology program, HT or HTL(ASCP) certification
• Experience validating RNAscope/miRNAscope and multiplex IHC/IF across multiple tissues/species
• Familiarity with LIMS/ELN
• Familiarity with digital pathology and whole-slide imaging