Scientist I

Responsibilities

• Execute and optimize the synthesis and characterization of lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro and in vivo studies under the guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Requirements, Knowledge, Skills, and Abilities

• Education: Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 2+ years of biopharma industry experience, OR a Master's degree with 1+ years of industry experience.
• LNP Expertise: Minimum of 1 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• PREFERRED SKILLS: Prior experience with Tangential Flow Filtration (TFF), dialysis, and bioconjugation chemistry is highly desirable.
• Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.