Scientist I

Key Responsibilities

• Independently design, develop, and execute a range of functional cell-based assays to validate novel targets, elucidate mechanisms of action, and demonstrate pharmacological activity in liver-relevant disease contexts.
• Establish and maintain primary hepatocyte cultures, iPSC-derived hepatocytes, and complex co-culture systems to generate robust functional readouts.
• Collaborate closely with the in vivo pharmacology team to design and execute ex vivo assays that characterize the pharmacodynamic effects of compounds, including target engagement, pathway modulation, and downstream biomarker readouts.
• Analyze and interpret complex datasets from multiple sources, draw conclusions, and maintain detailed, accurate lab records through Electronic Lab Notebook.
• Serve as a key biology contributor at the program team level; clearly present data, findings, and interpretation, and propose next steps informed by ongoing review of relevant scientific literature to cross-functional teams and company leadership.
• Work effectively with platform, data science, high-throughput screening, in vivo pharmacology and DMPK teams and deliver high-quality results in a timely fashion.
• Guide and mentor junior team members in the planning and execution of scientific experiments.

Required Qualifications

• Ph.D. in cell biology, molecular biology, biochemistry, pharmacology, or a related field; or M.S. with 6–9+ years of relevant experience.
• Demonstrated hands-on expertise in mammalian cell culture, including primary cells, iPSCs and co-culture models, with experience in stable cell line engineering.
• Proficiency in standard cell biology and molecular biology techniques (e.g., Western blot, ELISA, DNA/RNA extraction, RT-qPCR, immunofluorescence, flow cytometry).
• Strong analytical skills with the ability to critically evaluate complex biology problems and translate findings into clear recommendations.
• Effectively balances multiple priorities in a fast-paced environment, maintaining rigorous attention to detail and delivering high-quality data within established timelines.
• Strong verbal and written communication skills; able to convey complex scientific concepts and findings with clarity to matrixed teams.

Preferred Qualifications

• Experience with liver biology, liver disease models or metabolic diseases is highly preferred.
• Experience with oligonucleotide therapeutics is a strong plus.

Pay

$120,000 - $145,000 a year

Benefits

• Competitive compensation, including equity-based compensation
• A comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account
• Free parking