Scientist I – Cell Screening and Pharmacology, Discovery Technology

Responsibilities

• Design, build, and optimize the in vitro pharmacology assay cascade for DACs and biologics, from primary screening through mechanistic and quantitative characterization.
• Develop and perform cell-based assays to characterize DAC and biologic activity, including antigen binding, target engagement, and targeted protein degradation, using cutting-edge technologies and automated workflows.
• Cultivate and maintain mammalian cell lines (experience manipulating cell surface antigens and engineering reporter lines used to characterize DACs is preferred).
• Collaborate with team members to contribute to the design and execution of pharmacology studies to assess the biological activity and mechanism of action of lead molecules and drug candidates.
• Stay current with the latest scientific literature and industry developments in the fields of ADCs, DACs, biologics, and targeted protein degradation.
• Analyze, interpret, and clearly communicate results; present findings at internal meetings and contribute to scientific discussions that drive project advancement.

Qualifications

• D. in a relevant scientific field (Biochemistry, Pharmacology, Biology, etc.) with a strong academic track record, or MS with 6 or more years of relevant industry experience.
• Demonstrated experience designing and setting up in vitro pharmacology studies and screening cascades; prior know-how in building screening/assay cascades in the ADC or DAC field is preferred.
• Hands-on experience with mammalian cell culture and the ability to independently execute, analyze, and report results of quantitative cellular assays relevant to conjugate characterization (e.g., luminescence-based degradation, viability, or internalization assays).
• Experience with mechanistic assays that dissect DAC activity, such as antibody binding and intracellular drug release, is highly desired.
• Familiarity with automation equipment (e.g., liquid handlers) and automated workflows.
• Strong analytical and problem-solving skills, with sound judgment in evaluating and interpreting experimental results.

Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view