Scientist I / Scientist II, Cell-based High Throughput Screening
Neomorph, Inc. · San Diego Metropolitan Area · 2 days ago
On-siteScienceFull-time
We need to output only HTML fragment, using . The bullet points:
- Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
- Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
- Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
- Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
- Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
- Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
- Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
- Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
- Support assay transfer, validation, and implementation on automated HTS platforms.
- Perform other duties as assigned.
- Level-Specific Expectations: This includes details for Scientist I and Scientist II. Could be considered under "Requirements" or "Qualifications"? The posting has "Qualifications" later. The Level-Specific Expectations includes technical details about equipment and tasks. Might fit under "Skills" or "Requirements". We need to decide sections.
We have "Qualifications" section later: includes degree, experience guidelines, hands-on experience, etc. Also "Preferred Qualifications". So we can have a "Qualifications" section covering required qualifications, and maybe a "Preferred Qualifications" subsection? But we only have allowed headings: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We can use "Qualifications" for required qualifications, and maybe "Skills" for preferred qualifications or technical skills. Or we could combine.
We need to avoid filler like "commensurate with experience". Not present.
We need to include Pay/Benefits/Schedule only if posting states them. The posting includes "What we offer:" with compensation details: Industry-competitive compensation, Annual target bonus, Stock options, 401K plan, Career advancement opportunities, Monthly town halls, etc. Then benefits: Comprehensive medical, dental, vision, FSA/HSA, EAP, holidays, vacation, sick leave, supplemental pay for pregnancy disability, paid parental leave. Then lifestyle: Casual work environment, volunteer days, flexible schedule, onsite gym, bike/surfboard storage. Then "Have Fun!" etc. So we have benefits and maybe other perks. There's no explicit Pay or Schedule specifics (like salary range, hours). So we should not create Pay or Schedule sections because they are not stated. Benefits we can include as a section.
Thus sections: About the role, Responsibilities, Qualifications, Skills, Benefits. Possibly Requirements? The posting has "Qualifications" as a heading; we could treat that as Qualifications. The "Level-Specific Expectations" could be considered Requirements or Skills. Since we have both Qualifications and Skills allowed, we could put required qualifications under Qualifications, and technical skills/experience under Skills. Let's extract.
Required qualifications (under "Qualifications" heading):
- Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
- Level will be determined based on the candidate’s qualifications and alignment with the following general experience guidelines:
- Scientist I— PhD with relevant experience, MS with 8+ years of related experience or BS with 12+ years of relevant industry experience;
- Scientist II— PhD with 2 years of related experience, MS with 10+ years of relevant experience, or BS with 15+ years of relevant industry experience.
- Hands-on experience with mammalian cell culture, including maintenance, transfection or transduction, and banking of multiple cell lines.
- Experience developing or running quantitative cell-based assays using luminescence, fluorescence, time-resolved fluorescence, flow cytometry, high-content imaging, or related readouts.
- Understanding of assay-performance and screening-quality metrics such as Z', signal-to-background, coefficient of variation, and concentration-response analysis.
- Experience with laboratory automation, liquid handlers, plate readers, dispensers, or automated HTS workflows appropriate to career level.
- Strong organizational skills, attention to detail, scientific judgment, and ability to manage multiple workflows and timelines.
- Collaborative approach with strong verbal, written, and data-presentation skills.
Preferred Qualifications (under "Preferred Qualifications"):
- Experience transferring, validating, and implementing assays on automated HTS platforms.
- Experience with 384- and/or 1536-well assay formats and low-volume liquid handling.
- Familiarity with high-content imaging, multiplexed readouts, or flow cytometry-based screening.
- Experience generating stable cell lines or using inducible expression systems.
- Background in molecular biology techniques such as cloning, CRISPR editing, or viral-vector production.
We could put required qualifications under Qualifications, and preferred under Skills (or maybe also under Qualifications as a subsection). But we have a Skills heading allowed; we could put the preferred qualifications there as skills.
Also the Level-Specific Expectations includes details about equipment: Multi-mode plate readers, Flow cytometry platforms, Echo acoustic dispensers, LGR Precise Drop, Tecan Freedom EVO/Fluent, Hamilton Microlab STAR/NIMBUS, Beckman Biomek, Compound storage and retrieval systems, automated incubators, robotic plate handling, barcode tracking, LIMS integration, Automated screening workflows, Cell-based and biochemical assay development, miniaturization, validation, statistical analysis, quality-control assessment, Primary and secondary screening campaign execution, hit identification, data review, comprehensive screening documentation. For Scientist II: Programs and systems may include: Detection Instrumentation, Automated Liquid Handling Systems, Laboratory Automation Infrastructure, Assay Development and Screening Operations.
These are more like skills/experience. Could be placed under Skills as well.
Thus we can have Skills section covering: technical equipment expertise, level-specific expectations, preferred qualifications.
We must not invent content; just reformat.
Now Benefits section: list items from "What we offer:" and subsequent paragraphs.
We need to capture all substantive info: Industry-competitive compensation, Annual target bonus, Stock options, 401K plan, Career advancement opportunities, Monthly town halls to share business and scientific updates, Work Hard, Stay Well: Comprehensive medical, dental, and vision plans for employees and their dependents, Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution, Employee Assistance Program, 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave, Supplemental pay for Pregnancy Disability Leave, Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care, Lifestyle: Casual work environment, Volunteer days off each year to spend time contributing to causes you care about, Flexible work schedule, Access to onsite gym, Onsite space to store your bicycle (or surfboard), Have Fun!: department and company happy hours, regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
We should not include fluff like "Work Hard, Stay Well" as heading; just list items.
We need to ensure we don't include boilerplate like EEO etc. At the end there is EEO statement and notice to agencies; we must remove that.
Now produce HTML fragment with headings and
for section headings: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must include sections only when posting has real specific content. We must not repeat job title as heading. No Job ID etc. Remove boilerplate etc. We need to parse the posting. Key sections: - About the role: The first paragraph: "We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment." That's about the role. - Responsibilities: The bullet list under "Key Responsibilities". We need to list each bullet as
headings and - for lists,
for prose.
We need to decide which parts are prose vs list.
About the role: could be a paragraph (
) containing the description.
Responsibilities: list (
- each bullet).
Qualifications: list of required qualifications (
- ).
Skills: list of technical skills/preferred qualifications and level-specific expectations (
- ).
Benefits: list of benefits (
- ).
We must not include empty sections.
Let's craft.
First, About the role paragraph:
We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment.
Second, Responsibilities:
- Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
- Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
- Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
- Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
- Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
- Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
- Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
- Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
- Support assay transfer, validation, and implementation on automated HTS platforms.
- Perform other duties as assigned.
Third, Qualifications (required):
- Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
- Level will be determined based on the candidate’s qualifications and alignment with the following general experience guidelines: Scientist I— PhD with relevant experience, MS with 8+ years of related experience or BS with 12+ years of relevant industry experience; Scientist II— PhD with 2 years of related experience, MS with 10+ years of relevant experience, or BS with 15+ years of relevant industry experience.
- Hands-on experience with mammalian cell culture, including maintenance, transfection or transduction, and banking of multiple cell lines.
- Experience developing or running quantitative cell-based assays using luminescence, fluorescence, time-resolved fluorescence, flow cytometry, high-content imaging, or related readouts.
- Understanding of assay-performance and screening-quality metrics such as Z', signal-to-background, coefficient of variation, and concentration-response analysis.
- Experience with laboratory automation, liquid handlers, plate readers, dispensers, or automated HTS workflows appropriate to career level.
- Strong organizational skills, attention to detail,
for prose. We need to decide which parts are prose vs list. About the role: could be a paragraph (
) containing the description. Responsibilities: list (
- each bullet).
Qualifications: list of required qualifications (
- ).
Skills: list of technical skills/preferred qualifications and level-specific expectations (
- ).
Benefits: list of benefits (
- ).
We must not include empty sections.
Let's craft.
First, About the role paragraph:
We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment.
Second, Responsibilities:- Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
- Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
- Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
- Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
- Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
- Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
- Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
- Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
- Support assay transfer, validation, and implementation on automated HTS platforms.
- Perform other duties as assigned.
- Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
- Level will be determined based on the candidate’s qualifications and alignment with the following general experience guidelines: Scientist I— PhD with relevant experience, MS with 8+ years of related experience or BS with 12+ years of relevant industry experience; Scientist II— PhD with 2 years of related experience, MS with 10+ years of relevant experience, or BS with 15+ years of relevant industry experience.
- Hands-on experience with mammalian cell culture, including maintenance, transfection or transduction, and banking of multiple cell lines.
- Experience developing or running quantitative cell-based assays using luminescence, fluorescence, time-resolved fluorescence, flow cytometry, high-content imaging, or related readouts.
- Understanding of assay-performance and screening-quality metrics such as Z', signal-to-background, coefficient of variation, and concentration-response analysis.
- Experience with laboratory automation, liquid handlers, plate readers, dispensers, or automated HTS workflows appropriate to career level.
- Strong organizational skills, attention to detail,
- ).
We must not include empty sections.
Let's craft.
First, About the role paragraph:
- ).
Benefits: list of benefits (
- ).
Skills: list of technical skills/preferred qualifications and level-specific expectations (