Scientist, CNS Biology Research

Key Responsibilities

• Contribute to Alnylam’s growing pipeline by identifying new siRNA drug-targets that are based on human genetics, literature, academic collaborations, genomic approaches, etc. across the neurodegenerative space.
• Design and execute proof of concept experiments in animal and in vitro iPSC disease models.
• Design studies, coordinate activities, and lead from the bench.
• Serve as Biology Lead on select neurodegenerative/neuromuscular programs, overseeing lead discovery activities for the selection of drug candidates for further development.
• Work with multifunctional teams to shepherd a drug candidate through the lead selection and development process to the clinic.
• Manage relationships with contract research organizations (CROs) and/or academic collaborators, including development of research plans and data analysis.
• Mentor junior scientists.
• Collaborate and communicate results with key stakeholders throughout organization and external partners.

Qualifications

• PhD in biology or biomedical sciences-related field.
• Post doc in academia or industry or 1-2 years of experience preferred.
• Individuals with expertise in Amyotrophic Lateral Sclerosis (ALS) are strongly encouraged to apply.
• Strong publication record.
• In vitro technical skills including RNA and protein quantification, high-content image-based and functional assays related to disease biology, and single-cell RNA sequencing.
• Thorough understanding of relevant in vivo mammalian disease models strongly preferred, with experience in intracerebroventricular (ICV) injections, necropsy, behavioral analysis, ex vivo tissue processing, and downstream analysis including molecular and histological assessments.
• Strong organizational skills with the ability to proactively multitask are a must.
• Excellent interpersonal and communication skills with proven ability to work collaboratively in a fast-paced team environment.
• Genuine curiosity for learning new biology and a passion for hands-on laboratory work.

Pay

$110,400.00 - $165,600.00 per year

Benefits

Comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts, and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.