Scientist, Cell Biology & Antibody Engineering

About the role

The role is for a Scientist to join our team and develop and execute antibody screening and characterization on the Medra Physical AI platform. Key responsibilities include designing, executing, and interpreting antibody screening and characterization campaigns, running cell-based assays, and building out lab capabilities.

Responsibilities

• Design, execute, and interpret antibody screening and characterization campaigns across the full funnel
• Run cell-based binding and functional assays using flow cytometry to characterize antibodies, VHHs, and other binder formats
• Maintain and engineer mammalian cell lines and establish cell-based characterization and functional assays
• Develop and qualify new assays or platforms from scratch
• Translate manual assay workflows into reliable, high-throughput autonomous protocols on the Medra platform
• Partner with roboticists and software engineers to build out new lab capabilities
• Maintain rigorous experimental records in electronic lab notebooks and communicate results clearly to internal and external stakeholders

Requirements

• Ph.D. in cell biology, immunology, biochemistry, or a related discipline with 2+ years of industry experience, or a B.S./M.S. with 6+ years of deep, hands-on industry experience
• Strong background in mammalian cell culture and sterile technique, with a track record of maintaining healthy, reproducible cell lines for assay work
• Deep hands-on expertise in flow cytometry, including high-throughput formats and panel design
• Demonstrated experience designing and executing cell-based functional assays for antibody characterization
• Working understanding of antibody structure, function, and the therapeutic antibody discovery process
• Comfort establishing target-overexpressing cell lines and evaluating/implementing new assay technologies
• Strong documentation habits, attention to detail, and the ability to drive multiple workstreams in parallel

Qualifications

• Scrubbing skills and experience with sterile techniques
• Experience with alternative binder formats such as VHHs, bispecifics, Fc-fusions, ADCs, or non-Ig scaffolds
• Experience expressing and purifying antibodies in HEK293/CHO systems
• Experience with lab automation and liquid handling platforms

Skills

• Hands-on experience with lab automation and liquid handling platforms
• Experience expressing and purifying antibodies in HEK293/CHO systems
• Experience with alternative binder formats such as VHHs, bispecifics, Fc-fusions, ADCs, or non-Ig scaffolds

Benefits

• 401(k)
• Medical insurance and dental insurance
• Unlimited PTO
• Weekday lunches and dinners

Pay

$140K - $175K

Schedule

100% in-person, must be able to come on-site to our San Francisco office. Relocation benefits available.