Scientist/Senior Scientist, Antibody Engineering

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. Arrowhead’s RNAi technologies enable addressing conditions across virtually any therapeutic area, including disease targets not otherwise addressable by small molecules and biologics. The company is leading the field in bringing RNAi therapies to diseases outside the liver, with a clinical pipeline targeting the liver and lung, and a promising preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

We are seeking a highly motivated and skilled Molecular Biologist to join our dynamic research team in Discovery Chemistry. The successful candidate will play a key role in antibody engineering to support platform development and drug delivery initiatives. This position requires extensive hands-on experience in phage display, antibody engineering, and antibody characterization, supported by a strong foundation in molecular biology.

Responsibilities

• Design and construct mutant phage libraries for antibody affinity maturation or humanization.
• Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design.
• Express and purify recombinant antibodies using bacterial and mammalian expression systems.
• Perform binding, specificity, and in vitro functional assays.
• Collaborate with cross-functional project teams to advance lead antibodies through drug development stages.
• Maintain accurate documentation and present findings at internal meetings.

Requirements

• Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
• Hands-on experience with phage display technology for antibody engineering.
• Proficiency in molecular cloning, PCR, and mutagenesis.
• Experience with antibody expression and purification using E. coli, HEK293, and CHO systems.
• Strong analytical and problem-solving skills, with the ability to troubleshoot experiments independently.
• Excellent record-keeping, communication, and collaboration skills.
• Proven ability to adapt to a fast pace and evolving research priorities.
• Track record of scientific productivity, including peer-reviewed publications, conference presentations, or patents.

Preferred Qualifications

• Industry or postdoctoral experience.
• Additional experience in molecular biology and/or antibody discovery.

Pay

California pay range: $120,000–$150,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.