Scientist

About the role

The role involves driving the design, execution, and interpretation of studies supporting an engineered suppressor tRNA (sup-tRNA) pipeline in rare diseases. The Scientist will work closely with a cross-functional team to independently design, execute, and interpret in vivo and in vitro studies.

Responsibilities

• Independently designing, executing, and interpreting in vivo and in vitro studies evaluating AAV-delivered sup-tRNA gene therapy candidates, including dosing, tissue collection, and biodistribution and efficacy assessments.
• Leading the characterization of novel disease models through integrated molecular, biochemical, and functional analyses to inform go/no-go decisions.
• Applying quantitative molecular techniques (e.g., ddPCR, qPCR/RT-qPCR) to measure vector genomes, transgene and target protein expression, and biodistribution.
• Assessing protein-level readouts of therapeutic efficacy via JESS Western blot, ELISA, immunohistochemistry, MSD, or related methods.
• Contributing scientific strategy and study design input to IND-enabling packages, target product profiles, and regulatory or partnering documents.
• Presenting data and recommendations to the leadership team, translating complex datasets into clear conclusions.
• Collaborating cross-functionally with CMC, analytical development, and external CROs/CDMOs, and mentoring junior scientists as needed.
• Maintaining rigorous documentation and experimental records consistent with GLP-adjacent and IND-enabling study expectations.

Requirements

• Education: A BS, MS or PhD in a biological or chemical discipline is required.
• Experience: Several years of relevant industry experience is necessary. Prior experience in the biotech or pharmaceutical industry, ideally within a gene therapy, rare disease, or drug discovery/development setting, is expected. A demonstrated track record of designing and independently executing experiments and studies is required.
• Technical Skills: Hands-on expertise in molecular and protein-based assays (e.g., ddPCR/qPCR, Western blot, ELISA, IHC) is needed. In vivo experience in rodent models, such as dosing, tissue collection, necropsy/dissection, and behavioral or functional phenotyping, is also required.

Preferred Qualifications

• Experience with AAV biology and workflows, including vector titering.
• Strong mathematical skills are preferred.
• A collaborative, team-oriented working style paired with the independent judgment to drive projects forward proactively in a fast-paced environment.
• Strong scientific communication skills, with the ability to synthesize data for both technical and cross-functional audiences.

Benefits

Everforth Apex offers a comprehensive benefits package including medical, dental, vision, life, disability, and other insurance plans, an ESPP (employee stock purchase program), a 401K program with a company match, and a Health Savings Account (HSA) on the HDHP plan. Additionally, there is a SupportLinc Employee Assistance Program (EAP) with up to 8 free counseling sessions, a corporate discount savings program, and other discounts. Professional development includes an on-demand training program, access to certification prep and a library of technical and leadership courses/books/seminars, and certification discounts and perks for associations like CompTIA and IIBA. For more information, refer to the Welcome Packet provided by Everforth Apex.

Schedule

The role is full-time and based in Cambridge, MA.

Pay

The salary range for this position is $80,000 - $120,000 annually, depending on experience and qualifications.

Contact Information

To apply for this job, please visit our website or contact our Benefits Department at [email protected] or 804-523-8228. For ADA accommodations, please contact the Benefits Department at the same email or phone number.

Equal Opportunity Employer

We are committed to providing equal employment opportunities to all individuals without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or status as a protected veteran or person with a disability. We do not discriminate against applicants or employees based on these characteristics.